ArticleClinical and translational science2026
Population Pharmacokinetics of Vancomycin in Critically Ill Patients Undergoing Continuous Renal Replacement Therapy: Influence of Adsorptive Membranes.
Article in Clinical and translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Impact of adsorptive CRRT membranes on vancomycin pharmacokinetics in critically ill patients.Renal failure · 2026Review
- Neutrophil extracellular traps and acute kidney injury: a narrative review.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vancomycin is commonly used to treat Staphylococcus aureus infections. In critically ill patients receiving continuous renal replacement therapy (CRRT), adsorptive membranes like oXiris may alter drug pharmacokinetics. This retrospective study developed a population pharmacokinetics (PopPK) model using MonolixSuite software, incorporating adsorptive membrane use as a covariate. The final one-compartment model estimated that the population volume of distribution of vancomycin was 94.97 L (RSE 10.5%) and population clearance was 2.82 L/h (RSE 19.0%). Adsorptive membrane use was a significant covariate, slightly increasing vancomycin clearance, while aging was associated with reduced clearance. Monte Carlo simulations indicated that a regimen of 2 g loading dose followed by 1 g every 24 h achieved an AUC
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Registered trials
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