ArticleACS biomaterials science & engineering2026
Biomaterial Screening Identifies Enhanced Osteogenic and Angiogenic Potential of Mn-Doped Calcium Phosphate Coatings.
Article in ACS biomaterials science & engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synthetic biomaterials such as calcium phosphate (CaP) ceramics are promising substitutes for autologous bone grafts, as they are easy to produce, cost-effective and closely resemble the mineral component of natural bone. However, their performance in bone repair and regeneration is often inferior to their biological counterparts, which highlights the need for further optimization and improvement. Incorporating inorganic additives has previously been shown as a promising approach to improve the performance of synthetic biomaterials, without compromising their synthetic character. Here, a library of carbonated apatite coatings with inorganic additives such as copper, magnesium, manganese, strontium, and zinc was established. Human mesenchymal stem cells (hMSCs) were seeded on these coatings. A CaP coating with high (1000 μM) manganese incorporation (CaMnP1000) stood out as material inducing a superior osteogenic response in hMSCs, based on a protein multiplex assay containing markers related to osteogenesis, angiogenesis and inflammation. Specifically, the levels of osteopontin, bone morphogenetic protein-2, matrix metalloproteinase-13 and tenascin-C were increased relative to the control group, as well as mRNA transcripts related to early and late osteogenic gene expression (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.