Evidence map›Paper›PMID 41720401›Full record

ArticleJournal of lipid research2026

Aggressive cholesterol lowering normalizes atherosclerosis regression in Jak2

Brian D Hardaway, Trevor P Fidler, Mojdeh Tavallaie, Cheng-Chieh Hsu, Sandra Schiavone, Tong Xiao, Ranran Wang, Nan Wang, Alan R Tall

Abstract read
In one paragraph

Article in Journal of lipid research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Arteriosclerosis, thrombosis, and vascular biology · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Brian D HardawayDivision of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Trevor P FidlerCardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.
Mojdeh TavallaieDivision of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Cheng-Chieh HsuDivision of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Sandra SchiavoneDivision of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Tong XiaoDivision of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Ranran WangDivision of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Nan WangDivision of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Alan R TallDivision of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA. Electronic address: art1@cumc.columbia.edu.

Funding

Mouse and Human Atherosclerotic TissueP01HL172741 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ALAN richard TALL · 2024 to 2026
$9.5M
Cholesterol efflux, CHIP and inflammasome activationR01HL107653 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ALAN richard TALL · 2011 to 2026
$7.7M
JAK2V617F, clonal hematopoiesis and atherosclerosisR01HL148071 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI NAN WANG · 2019 to 2026
$4.0M
Clonal hematopoiesis, inflammasomes and atherosclerosisR01HL155431 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ALAN richard TALL · 2021 to 2026
$3.7M
The role of eosinophil in thrombosis and atherosclerosis in LNK deficiencyR01HL168392 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI NAN WANG · 2024 to 2026
$1.9M
New therapeutic approaches in clonal hematopoiesis and atherosclerosisR01HL170157 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI TALL, ALAN RICHARD · 2023 to 2023
$695k
NHLBI NIH HHS P01 HL172741NHLBI NIH HHS R01 HL107653NHLBI NIH HHS R01 HL148071NHLBI NIH HHS R01 HL155431NHLBI NIH HHS R01 HL168392NHLBI NIH HHS R01 HL170157
6 · The paper itself

Abstract

The Jak2

Indexed as

AtherosclerosisCholesterolJanus Kinase 2AnimalsMacrophagesMiceMice, Inbred C57BLMutationReceptors, LDLCholesterolJak2 protein, mouseJanus Kinase 2Receptors, LDLabsent in melanoma 2atherosclerotic plaque regressionbone marrowclonal hematopoiesisfoam cellsinflammasomeinflammationJak2(V617F) mutationLDLvascular biology

Identifiers

PMID41720401
PMCPMC13014939

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.