Evidence map›Paper›PMID 41720283›Full record

Trial reportAmerican heart journal2026

A comprehensive set of per-protocol analyses of the myocardial ischemia and transfusion (MINT) trial.

Brandon M Herbert, Jeffrey L Carson, Marnie Bertolet, John H Alexander, Shaun G Goodman, Dean A Fergusson, Gregory Ducrocq, Renato D Lopes, Tabassome Simon, Philippe Gabriel Steg and 3 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American heart journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Brandon M HerbertDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA.
Jeffrey L CarsonDivision of General Internal Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ.
Marnie BertoletDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA.
John H AlexanderDuke Clinical Research Institute, Duke University, Durham, NC.
Shaun G GoodmanSt. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada; Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada; Canadian VIGOUR Centre, University of Alberta, Edmonton, Alberta, Canada.
Dean A FergussonOttawa Hospital Research Institute, Ottawa, Ontario, Canada.
Gregory DucrocqUniversité de Paris, Assistance Publique-Hôpitaux de Paris (AP-HP), French Alliance for Cardiovascular Trials (FACT), Paris, France.
Renato D LopesDuke Clinical Research Institute, Duke University, Durham, NC.
Tabassome SimonSorbonne Université, Paris, France; Assistance Publique - Hospitaux de Paris (AP-HP), Service de Pharmacologie, Plateforme de Recherche, Clinique de l'Est Parisien, Hospital Saint Antoine, Paris, France; French Alliance for Cardiovascular Trials (FACT), Paris, France.
Philippe Gabriel StegFrench Alliance for Cardiovascular Trials (FACT), Paris, France; Université Paris-Cité, Paris, France.
Paul C HebertBruyere Health Research Institute, University of Ottawa, Ontario, Canada.
Maria Mori BrooksDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA. Electronic address: mbrooks@pitt.edu.
MINT Investigators

Funding

Myocardial Ischemia and Transfusion (MINT) - CCCU01HL133817 · NHLBI · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI CARSON, JEFFREY LEE · 2016 to 2022
$17.1M
Myocardial Ischemia and Transfusion (MINT) - DCCU01HL132853 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BROOKS, MARIA MORI · 2016 to 2022
$4.1M
NHLBI NIH HHS U01 HL132853NHLBI NIH HHS U01 HL133817
6 · The paper itself

Abstract

We conducted a series of analyses to estimate the per-protocol effect of restrictive versus liberal transfusion strategies on 30-day death and death or recurrent myocardial infarction (MI) among patients from the Myocardial Ischemia and Transfusion (MINT) trial. Multiple analytic approaches were used to estimate the per-protocol effect, including analyses based on different definitions of adherence (site-reported, time-based, transfusion delay) and an instrumental variable analysis. Analyses based on adherence definitions found a restrictive strategy was associated with a substantially greater risk of 30-day death or recurrent MI, while the instrumental variable analysis estimated a moderate treatment effect similar to the original ITT result.

Indexed as

Blood TransfusionMyocardial InfarctionMyocardial IschemiaAgedFemaleHumansMaleMiddle AgedRecurrence

Identifiers

PMID41720283
PMCPMC13296679

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.