ArticleThe Journal of pediatrics2026
Diagnostic Accuracy of Urine Microbial Diversity and Urine Neutrophil Gelatinase-Associated Lipocalin for the Diagnosis of Urinary Tract Infections in Children with Spina Bifida.
Article in The Journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
objectiveTo assess the predictive accuracy of urine neutrophil gelatinase-associated lipocalin (NGAL) and the Shannon Diversity Index in diagnosing urinary tract infection (UTI) in children with spina bifida. STUDY
designThis was a cross-sectional study of children with spina bifida who were evaluated for UTI in the emergency department. We included patients younger than the age of 22 years with spina bifida who used clean intermittent catheterization and had a urinalysis and urine culture sent. We measured urine NGAL and completed 16SrRNA sequencing. We generated receiver operating characteristic curves to assess the predictive accuracy of urinary NGAL and Shannon Diversity Index.
resultsThere were 51 children, 13 with UTI, in this study. The median Shannon Diversity Index was lower in children with UTI compared with those without, whereas median NGAL was significantly greater in the UTI vs the no-UTI group. The area under the curve for the combination of NGAL and Shannon Diversity was 0.88 (0.78-0.99), which is not significantly different from either the under the curve for NGAL or Shannon Diversity Index alone. NGAL was more specific, whereas the Shannon Diversity Index was more sensitive for the diagnosis of UTI.
conclusionsNGAL is specific, and Shannon Diversity Index is sensitive, for diagnosing UTI in children with spina bifida who use clean intermittent catheterization. However, the combination of the 2 markers does not create improved predictive accuracy over either alone.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.