ArticleJACC. Advances2026
Natural Shear Wave Elastography: A Promising Tool to Assess Myocardial Stiffness in Fontan Patients.
Article in JACC. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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15 authors.
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Abstract
backgroundNoninvasive assessment of myocardial properties and hemodynamics in Fontan patients remains challenging. Natural shear wave (SW) elastography is a promising new echocardiographic modality that allows noninvasive assessment of myocardial stiffness using the velocity of naturally occurring SWs detected with high frame rate (HFR) imaging.
objectivesThe objectives of the study were to document SW speed after atrioventricular valve closure (AVVC) and outflow valve closure in Fontan patients; to compare it with age-matched healthy volunteers; and to investigate the relation between SW speed, clinical features, and systemic venous pressures (SVPs).
methodsThe authors enrolled 47 Fontan patients (mean age: 19 ± 11 years, range 3-46y range: 3-46 years). For all, we acquired clinical data, conventional echocardiographic parameters, HFR parasternal long-axis views, and SVP when available (n = 30). HFR images were processed offline by extracting tissue Doppler acceleration color-coded maps of M-modes drawn in the middle of the wall related to both the inflow and the outflow valve.
resultsAverage SW speeds were higher in Fontan patients than in healthy volunteers (5.3 ± 1.6 m/s vs 3.0 ± 0.5 m/s after AVVC, P < 0.001; 5.1 ± 2.0 m/s vs 3.4 ± 0.6 m/s after outflow valve closure , P < 0.001). Patients with Fontan circulatory failure had increased SW speed compared to well-functioning Fontan patients (6.3 ± 1.4 m/s vs 4.9 ± 1.5 m/s; P = 0.008). SW velocities after AVVC correlated moderately to SVP (r = 0.55, P = 0.002), whereas no other conventional diastolic parameter did.
conclusionsOur findings suggest that Fontan hearts may be stiffer than normal and that SW velocities are higher in patients with a Fontan circulatory failure. Moreover, SW speed was related to SVP.
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