Foundation Model Based on Routine Magnetic Resonance Imaging for Brain Tumor Molecular Profiling and Progression Prediction.

purposeTo build a self-supervised magnetic resonance imaging (MRI) foundation model from routine clinical scans and to test whether it can support key glioma-related applications, including post-therapy imaging outcome characterization and molecular marker inference. MATERIALS AND

methodsWe created the Unified Multimodal Brain Imaging Foundation (UMBIF) model and pretrained it in a self-supervised manner using 51,029 routine brain MRI examinations collected across multiple institutions. Pretraining used a hybrid objective that couples masked-image reconstruction with contrastive representation learning to encourage anatomically and clinically informative embeddings. The pretrained UMBIF encoder was then adapted to downstream multicenter data sets to predict (1) post-treatment radiographic outcomes and (2) molecular biomarkers, including

resultsRelative to self-supervised initialization derived from natural-image corpora or from approaches emphasizing only large tumor-area crops (self-supervised learning [SSL]-ImageNet and SSL-Cerebral), the UMBIF encoder-decoder design captured richer, more task-relevant features and consistently improved downstream discrimination. The best pretrained model achieved an accuracy of 0.899 (AUC, 0.815) for post-treatment radiographic outcome characterization. For molecular profiling, it reached accuracies/AUCs of 0.898/0.916 for 1p/19q codeletion, 0.829/0.896 for

conclusionUMBIF showed robust transferability to both post-therapy imaging assessment and molecular status prediction in glioma. By leveraging large-scale self-supervised pretraining to boost performance while reducing dependence on manual annotations, the framework may facilitate more efficient and reliable diagnostic workflows.