ArticleBlood advances2026
Sickle cell vaso-occlusive episodes correlate with the magnetic heterogeneity of red blood cells.
Article in Blood advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
Abstract
abstractSickle cell disease (SCD) is a complex condition that results in low oxygen affinity and oxidative damage within red blood cells (RBCs), which contributes to serious complications such as vaso-occlusive episodes (VOEs). Given the well-established theoretical and experimental evidence that oxygenated hemoglobin is diamagnetic, whereas deoxygenated hemoglobin and methemoglobin are paramagnetic, this study aims to investigate whether RBCs from patients with SCD exhibit progressively increased magnetic susceptibility in correlation with disease severity. In this study, we employed cell tracking velocimetry (CTV) to perform single-cell analysis of RBC magnetic properties under both oxygenated and deoxygenated states. CTV quantifies the oxygen saturation of each cell by measuring their magnetically induced cell velocities in conjunction with known cell properties. Subsequent statistical analysis revealed that although the mean oxygen saturation of the RBCs from patients with SCD did not differ significantly from that of healthy donors, the magnetic velocities at the 1st and 99th percentile of RBC samples from patients with SCD were significantly reduced and elevated, respectively. These elevated and reduced velocities correlate directly to the magnetic susceptibility of the cell, which corresponds to the hemoglobin state. Moreover, we identified a correlation (P< .01) between magnetic heterogeneity in the top and bottom 1% and pain severity, particularly in patients with SCD experiencing acute VOEs. This study underscores the potential of RBC magnetic properties as biophysical markers for identifying the pain severity in patients with SCD and opening avenues for personalized therapeutic interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.