ArticleThe Journal of international medical research2026
Evaluating the causal effects of circulating plasma proteins on the risk of malignant neoplasms of bone and articular cartilage.
Article in The Journal of international medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
BackgroundMalignant neoplasms of bone and articular cartilage represent a rare group of highly invasive tumours with a poor prognosis, whose molecular mechanisms remain incompletely understood. Systematic identification of potential pathogenic proteins holds significance for early diagnosis and targeted therapy.MethodsA genetic tool was constructed using nine large-scale cis-protein quantitative trait loci (pQTL) datasets. Dual-sample Mendelian randomisation analysis was performed with plasma proteins as exposure and malignant neoplasms of bone and articular cartilage risk as the outcome. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed on proteins showing suggestive causal associations (
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