Evidence map›Paper›PMID 41719410›Full record

ArticleScience advances2026

CH•••S hydrogen bonds drive molecular recognition of ergothioneine by the microbial transporter.

Katherine A Legg, Giovanni Gonzalez-Gutierrez, Katherine A Edmonds, Philip G Shushkov, David P Giedroc

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Katherine A LeggDepartment of Chemistry, Indiana University, Bloomington, IN, USA.ORCID 0000-0002-3508-8765
Giovanni Gonzalez-GutierrezDepartment of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN, USA.ORCID 0000-0002-1044-943X
Katherine A EdmondsDepartment of Chemistry, Indiana University, Bloomington, IN, USA.ORCID 0000-0002-1282-9858
Philip G ShushkovDepartment of Chemistry, Indiana University, Bloomington, IN, USA.ORCID 0009-0000-6989-7416
David P GiedrocDepartment of Chemistry, Indiana University, Bloomington, IN, USA.ORCID 0000-0002-2342-1620

Funding

New Regulatory Interactions and Circuits that Mediate the Dynamics, Homeostasis, and Stress Responses of Peptidoglycan Synthesis in the Superbug Streptococcus pneumoniaeR35GM131767 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI MALCOLM E. WINKLER · 2019 to 2026
$4.8M
Acquisition of an 800 MHz hybrid solution-/solid-state NMR spectrometerS10OD032431 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI GIEDROC, DAVID P. · 2023 to 2023
$2.0M
NIGMS NIH HHS R35 GM131767NIH HHS S10 OD032431
6 · The paper itself

Abstract

Many bacteria harbor an ATP-binding cassette (ABC) transporter named EgtU specific for the human dietary antioxidant and 2-thioimidazole-containing low-molecular weight thiol ergothioneine (ET). How the solute binding domain, EgtUC, discriminates among ET and other similar molecules is unknown. Here, we use a "chimeric" mutagenesis strategy and two distantly related EgtUCs from

Indexed as

ATP-Binding Cassette TransportersBacterial ProteinsErgothioneineHelicobacter pyloriStreptococcus pneumoniaeBinding SitesHydrogen BondingModels, MolecularProtein BindingATP-Binding Cassette TransportersBacterial ProteinsErgothioneine

Identifiers

PMID41719410
PMCPMC12922746

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.