Evidence map›Paper›PMID 41719391›Full record

ArticleScience advances2026

12R-HETE acts as an endogenous ligand for Nur77 in the intestines and regulates NKp46

Ningning Huang, Zhipeng Yang, Yaojie You, Ling Ye, Hao Li, Jian Peng, Hongkui Wei

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ningning HuangDepartment of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.ORCID 0009-0004-4534-7013
Zhipeng YangDepartment of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.ORCID 0009-0003-6362-3651
Yaojie YouDepartment of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Ling YeDepartment of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.ORCID 0009-0003-5385-6494
Hao LiDepartment of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Jian PengDepartment of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Hongkui WeiDepartment of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.ORCID 0000-0001-7386-9936

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

How intestinal immunity develops during early life remains a key question in understanding defense against infections. Group 3 innate lymphoid cells (ILC3s) are critical for this defense, and their developmental progression and subset balance are essential for effective immune function. Here, we show that the nuclear receptor Nur77 helps control NKp46

Indexed as

Antigens, LyIntestinesLymphocytesNatural Cytotoxicity Triggering Receptor 1Nuclear Receptor Subfamily 4, Group A, Member 1AnimalsImmunity, InnateInterferon-gammaLigandsMiceMice, KnockoutSalmonella typhimuriumT-bet Transcription FactorT-Box Domain ProteinsAntigens, LyInterferon-gammaLigandsNatural Cytotoxicity Triggering Receptor 1Ncr1 protein, mouseNr4a1 protein, mouseNuclear Receptor Subfamily 4, Group A, Member 1T-bet Transcription FactorT-Box Domain Proteins

Identifiers

PMID41719391
PMCPMC12922749

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.