Evidence map›Paper›PMID 41719383›Full record

ArticleScience immunology2026

Monocyte-derived IL-10 drives sex differences in pain duration.

Jaewon Sim, Elizabeth O'Guin, Chiho Sugimoto, Sophie Laumet, Karli Monahan, Matthew P Bernard, Samuel A McLean, Liz M Albertorio-Sáez, Ying Zhao, Hariharan Ramakrishnan and 9 more

Abstract read
In one paragraph

Article in Science immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Jaewon SimDepartment of Physiology, Michigan State University, East Lansing, MI, USA.ORCID 0009-0007-4560-3525
Elizabeth O'GuinDepartment of Physiology, Michigan State University, East Lansing, MI, USA.
Chiho SugimotoDepartment of Physiology, Michigan State University, East Lansing, MI, USA.ORCID 0000-0002-4577-2659
Sophie LaumetDepartment of Physiology, Michigan State University, East Lansing, MI, USA.
Karli MonahanDepartment of Physiology, Michigan State University, East Lansing, MI, USA.
Matthew P BernardDepartment of Pharmacology & Toxicology, Michigan State University, East Lansing, MI, USA.ORCID 0000-0002-5950-3580
Samuel A McLeanDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Liz M Albertorio-SáezInstitute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0003-3419-5849
Ying ZhaoInstitute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0001-6781-092X
Hariharan RamakrishnanDepartment of Physiology, Michigan State University, East Lansing, MI, USA.
Sabrina de SouzaDepartment of Physiology, Michigan State University, East Lansing, MI, USA.ORCID 0000-0002-2422-1313
Olivia C EllerDepartment of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA.ORCID 0000-0001-7694-855X
Christine J SmoyerKansas Intellectual and Developmental Disabilities Research Center, University of Kansas Medical Center, Kansas City, KS, USA.ORCID 0009-0002-3838-3257
Kyle M BaumbauerDepartment of Cell Biology and Physiology, University of Kansas Medical Center, Kansas City, KS, USA.ORCID 0000-0003-0437-9209
Matthias MackDepartment of Nephrology, University Hospital Regensburg, Regensburg, Germany.ORCID 0000-0002-3157-7262
Joseph K FolgerDepartment of Physiology, Michigan State University, East Lansing, MI, USA.ORCID 0000-0001-9928-3853
Alfred J RobisonDepartment of Physiology, Michigan State University, East Lansing, MI, USA.ORCID 0000-0002-4150-9570
Sarah D LinnstaedtInstitute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0001-5295-7072
Geoffroy LaumetDepartment of Physiology, Michigan State University, East Lansing, MI, USA.ORCID 0000-0001-6752-3592

Funding

Longitudinal Assessment of Post-traumatic SyndromesU01MH110925 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KESSLER, RONALD C, KOENEN, KARESTAN C · 2016 to 2020
$25.8M
FKBP51 antagonism to prevent chronic pain: optimizing efficacy & evaluating safety and mechanismsR01NS118563 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LINNSTAEDT, SARAH, MCLEAN, SAMUEL A. · 2020 to 2024
$3.4M
Transcriptional mechanisms in mast cells underlying immune function and diseaseR01AI168014 · NIAID · MICHIGAN STATE UNIVERSITY · PI Adam Moeser, ALFRED J ROBISON · 2022 to 2026
$2.9M
Neuroimmune interactions regulating the balance between remission and relapse of painR01NS121259 · NINDS · MICHIGAN STATE UNIVERSITY · PI LAUMET, GEOFFROY O · 2021 to 2025
$2.0M
NHERF1 regulates MRGPRX2/MrgprB2 responses in mast cellsR01AI177305 · NIAID · MICHIGAN STATE UNIVERSITY · PI Geoffroy O Laumet, Adam Moeser · 2023 to 2026
$1.4M
Sex-dependent microRNA-mediated pathways to chronic musculoskeletal pain following traumaR01AR081454 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LINNSTAEDT, SARAH · 2024 to 2025
$950k
Spinning-Disk Confocal Microscope for Wide-Field, Super-Resolution, and Live-Cell ImagingS10OD032207 · OD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SMITH, PETER G · 2022 to 2022
$600k
Key Molecular Mechanisms of Chronic Pain Vulnerability in Women Experiencing MVCK01AR071504 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LINNSTAEDT, SARAH · 2018 to 2021
$502k
Explore the role of a new chemokine to alleviate postoperative painR21NS142685 · NINDS · MICHIGAN STATE UNIVERSITY · PI LAUMET, GEOFFROY O · 2025 to 2025
$432k
Circuit-specific androgen receptor regulation of hippocampal neuronal excitabilityF31MH134532 · NIMH · MICHIGAN STATE UNIVERSITY · PI SUGIMOTO, CHIHO · 2024 to 2025
$63k
NIAID NIH HHS R01 AI168014NIAID NIH HHS R01 AI177305NIAMS NIH HHS K01 AR071504NIAMS NIH HHS R01 AR081454NIH HHS S10 OD032207NIMH NIH HHS F31 MH134532NIMH NIH HHS U01 MH110925NINDS NIH HHS R01 NS118563NINDS NIH HHS R01 NS121259NINDS NIH HHS R21 NS142685
6 · The paper itself

Abstract

Women frequently experience longer-lasting pain than men, indicating delayed pain resolution, but the mechanisms underlying this sex difference remain unclear. Here, we show that interleukin-10

Indexed as

Interleukin-10MonocytesPainAnimalsFemaleHumansMaleMiceMice, Inbred C57BLMice, KnockoutSensory Receptor CellsSex CharacteristicsIL10 protein, mouseInterleukin-10

Identifiers

PMID41719383
PMCPMC13198883

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.