Evidence map›Paper›PMID 41719374›Full record

ArticlePLoS computational biology2026

CA-CAE: A deep learning-based multi-omics model for pan-cancer subtype classification and prognosis prediction.

Shumei Zhang, Yicheng Lu, Peixian Li, Junxuan Wu, Guohua Wang, Wen Yang

Abstract read
In one paragraph

Article in PLoS computational biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shumei ZhangCollege of Computer and Control Engineering, Northeast Forestry University, Harbin, China.ORCID https://orcid.org/0000-0003-3946-2977
Yicheng LuCollege of Computer and Control Engineering, Northeast Forestry University, Harbin, China.ORCID https://orcid.org/0009-0007-9475-2391
Peixian LiCollege of Computer and Control Engineering, Northeast Forestry University, Harbin, China.
Junxuan WuCollege of Computer and Control Engineering, Northeast Forestry University, Harbin, China.
Guohua WangCollege of Computer and Control Engineering, Northeast Forestry University, Harbin, China.
Wen YangInternational Medical Center, Shenzhen University General Hospital, Shenzhen, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In cancer research, identifying cancer subtypes and evaluating prognosis are crucial for personalized diagnosis and treatment of cancer. With the advancement of high-throughput sequencing technologies, multi-omics data has become essential for cancer classification and prognostic analysis. By integrating deep learning techniques, it is possible to more accurately identify cancer subtypes, providing a robust basis for personalized treatment of cancer patients. In this study, we propose a convolutional autoencoder prognostic model incorporating a channel attention mechanism (CA-CAE). The model utilizes multi-omics data to predict survival-associated cancer subtypes and identify prognostic genes. We applied CA-CAE to multiple cancer types, successfully identifying subtypes in 15 distinct cancer types and revealing significant survival differences among these subtypes. Moreover, compared to traditional statistical methods and other deep learning approaches, CA-CAE demonstrated superior performance in predicting survival outcomes.

Indexed as

Deep LearningNeoplasmsAutoencoderClassification AlgorithmsComputational BiologyHumansMultiomicsPrediction AlgorithmsPredictive Learning ModelsPrognosis

Identifiers

PMID41719374
PMCPMC12948314

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.