Evidence map›Paper›PMID 41719275›Full record

ReviewPLoS pathogens2026

The crosstalk between acute hepatopancreatic necrosis disease (AHPND) and the Vibrio quorum sensing (QS) system: A review.

Hao-Ching Wang, Ramya Kumar, Michael Eniola Ayenero, Kai-Cheng Hsu, Chu-Fang Lo, Shin-Jen Lin, Han-Ching Wang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in PLoS pathogens, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hao-Ching WangGraduate Institute of Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan, ROC.ORCID https://orcid.org/0000-0003-2396-717X
Ramya KumarInternational Center for the Scientific Development of Shrimp Aquaculture, National Cheng Kung University, Tainan, Taiwan, ROC.
Michael Eniola AyeneroInternational PhD for Translational Science, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan, ROC.
Kai-Cheng HsuGraduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan, ROC.
Chu-Fang LoInternational Center for the Scientific Development of Shrimp Aquaculture, National Cheng Kung University, Tainan, Taiwan, ROC.
Shin-Jen LinInternational Center for the Scientific Development of Shrimp Aquaculture, National Cheng Kung University, Tainan, Taiwan, ROC.
Han-Ching WangInternational Center for the Scientific Development of Shrimp Aquaculture, National Cheng Kung University, Tainan, Taiwan, ROC.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute hepatopancreatic necrosis disease (AHPND) is a disease that has caused significant losses to shrimp farming since 2009. The primary mechanism of this disease involves the binary toxins PirAvp and PirBvp, which are produced by specific strains of Vibrio parahaemolyticus, and which lead to significant damage to the hepatopancreatic cells of shrimps. Recent studies on the pathology of AHPND have also highlighted the role of the Vibrio quorum sensing (QS) system, which affects growth, virulence, and biofilm regulation in Vibrio species. For example, deletion of the qseC gene reduces the virulence of the AHPND-causative V. parahaemolyticus. Most importantly, the QS regulators LuxOvp and AphBvp have been implicated as they control the growth-phase-dependent expression of the pirAvp/pirBvp genes. Additionally, given the growing problem of antibiotic resistance, this article reviews several alternative control strategies targeting the QS system, including QS inhibition using natural products, biofloc technology, and the development of small-molecule inhibitors against AphBvp. Finally, we also discussed the potential of using probiotics to enhance shrimp disease resistance through QS inhibition, highlighting the feasibility of targeting the QS system for AHPND control.

Indexed as

HepatopancreasPenaeidaeQuorum SensingVibrio InfectionsVibrio parahaemolyticusAnimalsVirulence

Identifiers

PMID41719275
PMCPMC12922982

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.