Evidence map›Paper›PMID 41718974›Full record

ReviewSub-cellular biochemistry2026

ARF GTPases Function at the Golgi.

Petia Adarska, Luis Wong-Dilworth, Francesca Bottanelli

Abstract readReview
PubMed Publisher
In one paragraph

Review in Sub-cellular biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Petia AdarskaInstitute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.
Luis Wong-DilworthInstitute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.
Francesca BottanelliInstitute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany. bottanelli@zedat.fu-berlin.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ADP-ribosylation factors (ARFs) are small (~21 kDa) GTPases that play a central role in intracellular transport across eukaryotic cells. Structurally related to Ras GTPases, ARFs were initially discovered as allosteric activators of cholera toxin but later emerged as key regulators of membrane trafficking. ARFs function through a GDP-GTP cycle, where guanine nucleotide exchange factors (GEFs) promote the exchange of GDP for GTP, activating ARFs and facilitating their membrane association. Conversely, GTPase-activating proteins (GAPs) stimulate GTP hydrolysis, leading to ARF inactivation and membrane dissociation. This cycle is crucial for ARF-mediated recruitment of cargo adaptors, coat proteins which regulate cargo selection and trafficking pathways through a close interplay with lipid-based signaling.

Indexed as

ADP-Ribosylation FactorsGolgi ApparatusAnimalsGTPase-Activating ProteinsGuanine Nucleotide Exchange FactorsGuanosine TriphosphateHumansProtein TransportSignal TransductionADP-Ribosylation FactorsGTPase-Activating ProteinsGuanine Nucleotide Exchange FactorsGuanosine TriphosphateARF GTPasesGDP-GTP exchange factorsGolgi traffickingGTPase activating proteins

Identifiers

PMID41718974

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.