ReviewIndian journal of gastroenterology : official journal of the Indian Society of Gastroenterology2026
Diagnostic performance of splenic stiffness measurement for prediction of esophageal/gastric varices in pediatric portal hypertension: A systematic review and meta-analysis.
Review in Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesEsophageal/gastric varices (EV), especially clinically significant varices (CSV), represent life-threatening complications of pediatric portal hypertension (PH), necessitating timely detection. While esophagogastroduodenoscopy (EGD) remains the gold standard, its invasive nature and requirement for sedation in children highlight the need for reliable non-invasive alternatives for screening and risk stratification. Splenic stiffness measurement (SSM) has emerged as a potential tool. This systematic review and meta-analysis aimed to evaluate diagnostic accuracy of SSM for detecting EV and CSV in pediatric PH.
methodsA comprehensive search of PubMed, Scopus and Embase was performed up to January 2025. Studies assessing SSM via elastography in pediatric (< 18 years) PH, with EGD as reference standard for EV/CSV detection, were included. Data was synthesized using hierarchical summary receiver operating characteristic (HSROC) model to estimate pooled sensitivity, specificity, diagnostic odds ratio (DOR) and area under the receiver operating characteristic curve (AUROC). Risk of bias was evaluated using Quality Assessment of Studies of Diagnostic Accuracy (QUADAS-2) tool.
resultsTen studies encompassing 618 patients were analyzed. For EV prediction (3 studies, n = 158), pooled sensitivity, specificity and DOR were 0.80 (95% CI: 0.70-0.88), 0.89 (95% CI: 0.80-0.95) and 26.22 (95% CI: 5.39-98.83), respectively, with AUROC 0.838 (95% CI: 0.806-0.864). For CSV (7 studies, n = 460), values were 0.86 (95% CI: 0.81-0.90), 0.82 (95% CI: 0.76-0.87) and 31.00 (95% CI:12.33-80.21) with AUROC 0.905 (95% CI: 0.882-0.924), indicating very good diagnostic performance. Substantial heterogeneity noted for pooled sensitivity (I
conclusionSSM demonstrates good diagnostic accuracy for non-invasive variceal predictionin pediatric PH. However, further multicentre studies with standardized protocols and disease-specific cut-offs for pediatric population are necessary for its integration in routine clinical practice as a screening tool.
Indexed as
Identifiers
41718928What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.