Evidence map›Paper›PMID 41718910›Full record

ArticleCancer causes & control : CCC2026

Childhood and Adolescent Factors and Thyroid Cancer Incidence in Adult Women in the Sister Study Cohort.

Thi-Van-Trinh Tran, Katie M O'Brien, Rebecca Troisi, Dale P Sandler, Cari M Kitahara

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Article in Cancer causes & control : CCC, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Thi-Van-Trinh TranRadiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Room 7E-456, Bethesda, MD, 20892-9778, USA.
Katie M O'BrienEpidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC, USA.
Rebecca TroisiDivision of Cancer Epidemiology and Genetics, Trans-Divisional Research Program, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Room 7E-456, Bethesda, MD, 20892-9778, USA.
Dale P SandlerEpidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC, USA.
Cari M KitaharaRadiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Room 7E-456, Bethesda, MD, 20892-9778, USA. kitaharac@mail.nih.gov.ORCID http://orcid.org/0000-0001-6416-4432

Funding

Genetic and Environmental Risk Factors for Breast Cancer: The Sister StudyZ01ES044005 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SANDLER, DALE P · 1999 to 2008
$1.3M
Intramural NIH HHS Z01 ES044005Intramural Research Program Z1AES044005
6 · The paper itself

Abstract

purposeDifferentiated thyroid cancer (DTC) is more common in women than in men but the etiology is not well understood. We therefore investigated the association between childhood and adolescent factors and subsequent DTC incidence in women.

methodsWe used data from 47,913 women enrolled (2003-2009) in the U.S. nationwide Sister Study cohort who were cancer-free at baseline. We used Cox regression models to assess associations of DTC incidence with self-reported baseline characteristics, including perceived body size, hormonal, lifestyle, and socioeconomic factors through age 20, adjusting for attained age (timescale), and race/ethnicity.

resultsOver follow-up (median: 13.1 years), 239 DTC cases were identified. Factors associated with higher DTC incidence included being taller than peers at age 10 (hazard ratio [HR] = 1.41, 95% confidence interval [CI] = 1.06-1.89), being lighter (HR = 1.37, 95%CI = 0.97-1.91) or heavier (HR = 1.28, 95%CI = 0.96-1.71) than peers during teen years, and ever not having enough to eat during childhood (HR = 1.67, 95%CI = 1.15-2.43). DTC incidence was lower among those with childhood higher household educational level (HR

conclusionOur findings suggest that childhood growth, nutrition, and socioeconomic factors may influence DTC incidence in women.

Indexed as

Thyroid NeoplasmsAdolescentAdultChildCohort StudiesFemaleHumansIncidenceMiddle AgedRisk FactorsSocioeconomic FactorsUnited StatesYoung AdultAdolescent exposuresChildhood exposuresIncidenceObservational studyRisk factorsThyroid neoplasms

Identifiers

PMID41718910
PMCPMC12923491

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.