Evidence map›Paper›PMID 41718796›Full record

Observational studyChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2026

Long-term outcomes of paediatric craniopharyngiomas: a comparison of two large international series.

Vitor Nagai Yamaki, Jai Sidpra, Bruno Santanna Peres, Valentina Lind, Catuto Domingos Alexandre Quianga, Guilherme Jose da Costa Borsatto, Joao Paulo Mota Telles, Inês Nobrega Silva, Juan Pedro Martinez-Barbera, Sniya Sudhakar and 10 more

Abstract readComparative StudyObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Vitor Nagai YamakiDepartment of Paediatric, Neurosurgery/Institute of Child Health, Great Ormond Street Hospital for Children, University College London (UCL), London, UK. vitoryamaki@gmail.com.
Jai SidpraDevelopmental Biology and Cancer Section, University, College London Great Ormond Street Institute of Child Health, London, UK.
Bruno Santanna PeresDepartment of Radiology, Hospital, das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil.
Valentina LindDepartment of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, UK.
Catuto Domingos Alexandre QuiangaDepartment of Neurosurgery, Hospital das Clínicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil.
Guilherme Jose da Costa BorsattoDepartment of Neurology, Laboratory of Molecular and Cellular, LIM 15, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Brazil.
Joao Paulo Mota TellesDepartment of Neurology, Laboratory of Molecular and Cellular, LIM 15, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Brazil.
Inês Nobrega SilvaDepartment of Paediatric, Neurosurgery/Institute of Child Health, Great Ormond Street Hospital for Children, University College London (UCL), London, UK.
Juan Pedro Martinez-BarberaDevelopmental Biology and Cancer Section, University, College London Great Ormond Street Institute of Child Health, London, UK.
Sniya SudhakarDepartment of Neuroradiology, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.
Asthik BiswasDepartment of Neuroradiology, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.
Kshitij MankadDepartment of Neuroradiology, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.
Hoong-Wei GanDepartment of Endocrinology, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.
Hani J MarcusDepartment of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, UK.
Dominic ThompsonDepartment of Paediatric, Neurosurgery/Institute of Child Health, Great Ormond Street Hospital for Children, University College London (UCL), London, UK.
Noor Ul Owase JeelaniDepartment of Neurosurgery, Hospital das Clínicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil.
Darren R HargraveDepartment of Oncology, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.
Hamilton MatushitaDepartment of Neurosurgery, Hospital das Clínicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil.
Suely Kazue Nagahashi MarieDepartment of Neurology, Laboratory of Molecular and Cellular, LIM 15, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Brazil.
Kristian AquilinaDepartment of Paediatric, Neurosurgery/Institute of Child Health, Great Ormond Street Hospital for Children, University College London (UCL), London, UK.

Funding

Conselho Nacional de Pesquisa CNPq #304541/2020-6Sao Paulo Research Foundation FAPESP; grants #2020/02988-7
6 · The paper itself

Abstract

purposeAdamantinomatous craniopharyngioma (ACP) is an uncommon and anatomically variable tumor in children. The balance between critical treatment objectives, including the pursuit of gross total surgical resection and the reduction of hypothalamic injury and tumor recurrence, remains difficult and controversial. In this retrospective observational study, we compare the management and outcome of ACP in two large paediatric neurosurgical centres to determine how variations in tumor characteristics and management influence long-term outcomes.

methodsIn this retrospective observational study, consecutive children (aged ≤ 18 years) diagnosed with primary ACP between 1997 and 2023 at two tertiary paediatric neurosurgical centres (Great Ormond Street Hospital (GOSH), United Kingdom, and Universidade de São Paulo (USP), Brazil) were evaluated. Functional outcomes related to pituitary function, hypothalamic injury, cognition, and vision were analysed. Scans were independently reviewed for tumor size, characteristics, and relationship to the optic apparatus and hypothalamus. Extent of surgery was documented.

results123 patients (USP = 52; GOSH = 71) were included. Mean follow-up was 10.1 ± 5.6 years at USP and 7.5 ± 4.8 years at GOSH. There were no demographic differences. Rates of growth hormone deficiency (USP = 62.5%; GOSH = 35%; p = 0.009) and visual deficits (p < 0.05) were higher in the USP cohort at initial presentation. Patients at GOSH presented with predominantly cystic lesions (n = 46/60; 76.7%) while at USP solid tumors (n = 24/32; 75%) (p = 0.05) were more prevalent. Paris grade for hypothalamic involvement was higher in the GOSH cohort (p = 0.01). Although gross total resection (GTR) was similar in the two groups, cyst aspiration plus radiotherapy was commoner at GOSH, whereas debulking was commoner at USP (p < 0.001). Post-treatment hypothalamic scores were better in the GOSH cohort (p < 0.04). Patients at GOSH had earlier recurrences (25.5 ± 32 months) compared to patients treated at USP (37.4 ± 59.5 months) (p = 0.01). In multivariate analysis, STR/GTR (OR 0.17; 95%CI:0.05-0.55, p < 0.01) and older age at diagnosis (OR 0.91, 95%CI:0.82-0.99, p = 0.04) were associated with longer progression-free survival.

conclusionComparative analysis of two large series of ACP in children identified different paradigms of surgical management driven by distinct clinical-radiological presentations. While cyst aspiration plus radiotherapy protects against hypothalamic injury, this may occur at the cost of earlier tumour recurrence. Further studies to define this balance are urgently needed. PREVIOUS PRESENTATIONS: 21st International Symposium on Pediatric Neuro-Oncology. June 29-July 2, 2024.

Indexed as

CraniopharyngiomaPituitary NeoplasmsAdolescentBrazilChildChild, PreschoolFemaleFollow-Up StudiesHumansMaleNeoplasm Recurrence, LocalNeurosurgical ProceduresRetrospective StudiesTreatment OutcomeUnited KingdomCognitive outcomesCraniopharyngiomaDiabetes insipidusHypothalamic diseases

Identifiers

PMID41718796
PMCPMC12923425

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.