ReviewHandbook of experimental pharmacology2026
Oxidative Modifications in Cardiac Mitochondrial and Ca
Review in Handbook of experimental pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity and its related comorbidities, collectively defined as metabolic syndrome (MetS), represent a major health concern due to their strong association with increased cardiometabolic risk. A defining feature of obesity and MetS is the excessive production of reactive oxygen species and reactive nitrogen species, resulting in systemic oxidative stress (OS) and nitrosative stress (NS). In the heart, OS and NS induce structural and conformational alterations in proteins, referred to as oxidative post-translational modifications (oxPTMs). These modifications disrupt protein function, thereby impairing essential cellular processes and ultimately contributing to diastolic and systolic dysfunction. Several proteins critical for cardiac function have been identified as targets of oxPTMs in the context of obesity and MetS. Among the most studied are mitochondrial proteins such as dynamin-related protein 1 (Drp1), respiratory chain complexes I, II, and IV, and creatine kinase, as well as Ca
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.