Evidence map›Paper›PMID 41718777›Full record

ReviewHandbook of experimental pharmacology2026

Sexual Dimorphism in the Development of Cardiometabolic Syndrome.

Myrian Velasco, Alondra Albarado-Ibañez, Carlos Larqué, Pablo Pánico, Julián Torres-Jacome, Marcia Hiriart

Abstract readReview
PubMed Publisher
In one paragraph

Review in Handbook of experimental pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Myrian Velasco *Department of Cognitive Neurosciences, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, México City, Mexico.
Alondra Albarado-Ibañez *Laboratorio de Fisiopatología Cardiovascular. Centro de Investigación Fisicoquímica de Materiales, Instituto de Ciencias, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico.
Carlos LarquéLaboratory of Embryology and Genetics, Departamento de Embriología y Genética, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Pablo PánicoDepartment of Genomic Medicine and Environmental Toxicology, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México City, Mexico.
Julián Torres-JacomeLaboratorio de Fisiopatología Cardiovascular. Centro de Investigación Fisicoquímica de Materiales, Instituto de Ciencias, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico.
Marcia HiriartDepartment of Cognitive Neurosciences, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, México City, Mexico. mhiriart@ifc.unam.mx.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anatomical and physiological differences between sexes explain the sexual dimorphism in the development of diseases, such as obesity and metabolic syndrome. This syndrome is a condition that increases the risk of developing cardiovascular diseases, diabetes, and certain cancer types. Cardiovascular diseases remain the leading cause of mortality in both sexes worldwide. However, CVD mortality is higher in men than women, demonstrating that the differences between women and men might have an essential role in the development of CVD.The CV system shows dimorphic variations, starting at early developmental stages. However, most studies on the CV system have been conducted predominantly in males. Understanding the differences in the CVD associated with sex is vital to improving the prevention, diagnosis, and treatment of these diseases. In this chapter, we highlight the differences found in the literature between sexes in physiological and pathological events within the cardiovascular system related to metabolic syndrome (MetS).

Indexed as

Cardiovascular DiseasesMetabolic SyndromeSex CharacteristicsAnimalsCardiovascular SystemFemaleHumansMaleRisk FactorsSinoatrial NodeCardioCardiovascular agingHeart rhythmMetabolic syndromeSexual dimorphismSinoatrial node

Identifiers

PMID41718777

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.