Evidence map›Paper›PMID 41718487›Full record

ArticleAntimicrobial agents and chemotherapy2026

Optimizing target inactivation to treat multidrug-resistant

Claudia Fabrizio, Felice Valzano, Simone Giuliano, Elisabetta Morelli, Daniela Serio, Giovanni Battista Buccoliero, Maurizio Cervellera, Gianfranco La Bella, Fabio Arena, Andrea M Hujer and 4 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Case Commentary: When susceptibility is not enough in recurrentAntimicrobial agents and chemotherapy · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Claudia FabrizioInfectious and Tropical Diseases Clinic, San Giuseppe Moscati Hospital, Taranto, Italy.ORCID 0000-0002-9057-490X
Felice ValzanoDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.ORCID 0000-0002-7638-1538
Simone GiulianoInfectious Diseases Clinic, Department of Medicine (DMED), University of Udine, Udine, Italy.
Elisabetta MorelliClinical Pathology Unit, SS Annunziata Hospital, Taranto, Italy.
Daniela SerioIntensive Care Unit, SS Annunziata Hospital, Taranto, Italy.
Giovanni Battista BuccolieroInfectious and Tropical Diseases Clinic, San Giuseppe Moscati Hospital, Taranto, Italy.
Maurizio CervelleraGeneral Surgery Unit, SS Annunziata Hospital, Taranto, Italy.
Gianfranco La BellaDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Fabio ArenaDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Andrea M HujerDepartment of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.ORCID 0009-0001-3543-1826
Magdalena A TaracilaDepartment of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Steven H MarshallResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
Robert A BonomoDepartment of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.ORCID 0000-0002-3299-894X
Carlo TasciniInfectious Diseases Clinic, Department of Medicine (DMED), University of Udine, Udine, Italy.ORCID 0000-0001-9625-6024

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 65-year-old man without identifiable risk factors for multidrug-resistant pathogens was admitted with peritonitis, isolating NDM-producing

Indexed as

Anti-Bacterial Agentsbeta-LactamasesDrug Resistance, Multiple, BacterialEscherichia coliEscherichia coli InfectionsPenicillin-Binding ProteinsAgedAzabicyclo CompoundsAztreonamCeftazidimeDrug CombinationsEscherichia coli ProteinsHumansImipenemMaleMicrobial Sensitivity TestsAnti-Bacterial Agentsavibactam, ceftazidime drug combinationAzabicyclo CompoundsAztreonambeta lactamase NDM-5, E colibeta-LactamasesCeftazidimeDrug CombinationsEscherichia coli ProteinsImipenemPenicillin-Binding ProteinsaztreonamCMYdouble β-lactam combinationsE. coliimipenem/relebactamNDM-5penicillin binding protein3

Identifiers

PMID41718487
PMCPMC13148025

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.