Evidence map›Paper›PMID 41718410›Full record

ArticleEpigenomes2026

Preliminary Evidence of Blood DNA Methylation Changes in Pregnant Women Adhering to a Mediterranean Diet.

Grace Tavelli, Nikki Schultz, Joanna Brisbane, Nina Kresoje, Samantha Lodge, Jeremy K Nicholson, Nicola J Armstrong, Desiree Silva, Nina D'Vaz, David Martino

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenomes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Grace TavelliThe Kids Research Institute Australia, Perth Children's Hospital, Nedlands, WA 6009, Australia.
Nikki SchultzThe Kids Research Institute Australia, Perth Children's Hospital, Nedlands, WA 6009, Australia.
Joanna BrisbaneThe Kids Research Institute Australia, Perth Children's Hospital, Nedlands, WA 6009, Australia.
Nina KresojeThe Kids Research Institute Australia, Perth Children's Hospital, Nedlands, WA 6009, Australia.
Samantha LodgeCentre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Perth, WA 6150, Australia.ORCID 0000-0001-9193-0462
Jeremy K NicholsonCentre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Perth, WA 6150, Australia.ORCID 0000-0002-8123-8349
Nicola J ArmstrongSchool of Population Health, Curtin University, Perth, WA 6102, Australia.ORCID 0000-0002-4477-293X
Desiree SilvaThe Kids Research Institute Australia, Perth Children's Hospital, Nedlands, WA 6009, Australia.
Nina D'VazThe Kids Research Institute Australia, Perth Children's Hospital, Nedlands, WA 6009, Australia.
David MartinoThe Kids Research Institute Australia, Perth Children's Hospital, Nedlands, WA 6009, Australia.ORCID 0000-0001-6823-4696

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesConsumption of a Mediterranean diet (MD) has been associated with reduced incidence of non-communicable diseases and reduced overall mortality, with epigenomic effects representing plausible mediators. The aim of this pilot study was to explore potential epigenetic associations between DNA methylation markers in blood and adherence to an MD in pregnancy.

methodsFifty-two pregnant women with high or low adherence to an MD throughout pregnancy, who participated in the BioMood ORIGINS study, were selected using an extremes-of-exposure design. DNA methylation (DNAm) profiles from whole blood were generated using the TWIST human methylome panel. We conducted both genome-wide and candidate gene-based differential methylation analyses to identify epigenetic variations between the study groups. Furthermore, we explored potential associations between blood methylation patterns and circulating inflammatory markers (GlycA, GlycB and SPC) previously observed to exhibit differential abundance in the same cohort of women.

resultsThere were no genome-wide significant differences in methylated dinucleotides between MD groups (

conclusionsWe provide preliminary evidence for modest methylation changes in specific genes associated with adherence to an MD.

Indexed as

epigeneticsMediterranean dietmethylationpregnancy

Identifiers

PMID41718410
PMCPMC12921938

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.