SynthesisJournal of the American Heart Association2026
Mothership Versus Drip-and-Ship Models in Acute Stroke Care: A Time-Sensitive Meta-Analysis.
Synthesis in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMechanical thrombectomy is the standard of care for acute ischemic stroke due to large vessel occlusion. Whether the mothership model or the drip-and-ship model provides superior outcomes remains unclear. This systematic review and meta-analysis aimed to compare functional and safety outcomes between these 2 models and assess the impact of onset-to-groin puncture delay on outcomes.
methodsWe conducted a systematic review and meta-analysis following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, registered in PROSPERO (International Prospective Register of Systematic Reviews; CRD420251034209). We searched PubMed, EMBASE, and Cochrane CENTRAL up to March 9, 2025. We included randomized trials, cohort studies enrolling patients with anterior circulation large vessel occlusion treated with mechanical thrombectomy. The primary outcome was 90-day functional independence (modified Rankin Scale score, 0-2). Secondary outcomes included excellent outcome (modified Rankin Scale score 0-1), successful recanalization, symptomatic intracranial hemorrhage, any intracranial hemorrhage, and 90-day mortality. Risk of bias was assessed using Risk of Bias in Non-randomized Studies of Interventions and Risk of Bias 2.0 tools. Meta-regression was performed to evaluate the effect of onset-to-groin puncture time differences on outcomes.
resultsNineteen studies (16 485 patients) were included. The mothership model and drip-and-ship model showed no significant difference in achieving 90-day functional independence (odds ratio, 1.12 [95% CI, 0.94-1.32]). Meta-regression showed that longer delays to thrombectomy in the drip-and-ship model significantly reduced the odds of functional independence (
conclusionsDirect transport to a thrombectomy-capable center should be prioritized when secondary transfer is expected to delay treatment, as functional outcomes worsen significantly beyond this threshold.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.