Article in Circulation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
13 authors.
Tomonori TadokoroDepartment of Molecular Biology (T.T., H.L., P.G., Z.X., W.T., D.A., E.S.-O., J.R.M., N.L., E.N.O.), University of Texas Southwestern Medical Center, Dallas.ORCID 0000-0002-7360-672X
Hui LiDepartment of Molecular Biology (T.T., H.L., P.G., Z.X., W.T., D.A., E.S.-O., J.R.M., N.L., E.N.O.), University of Texas Southwestern Medical Center, Dallas.ORCID 0000-0002-4114-8349
Peiheng GanDepartment of Molecular Biology (T.T., H.L., P.G., Z.X., W.T., D.A., E.S.-O., J.R.M., N.L., E.N.O.), University of Texas Southwestern Medical Center, Dallas.ORCID 0000-0001-8617-0606
Zhisheng XuDepartment of Molecular Biology (T.T., H.L., P.G., Z.X., W.T., D.A., E.S.-O., J.R.M., N.L., E.N.O.), University of Texas Southwestern Medical Center, Dallas.
Wei TanDepartment of Molecular Biology (T.T., H.L., P.G., Z.X., W.T., D.A., E.S.-O., J.R.M., N.L., E.N.O.), University of Texas Southwestern Medical Center, Dallas.ORCID 0000-0001-6008-3854
Damir AlzhanovDepartment of Molecular Biology (T.T., H.L., P.G., Z.X., W.T., D.A., E.S.-O., J.R.M., N.L., E.N.O.), University of Texas Southwestern Medical Center, Dallas.ORCID 0009-0008-8929-5226
Efraín Sánchez-OrtizDepartment of Molecular Biology (T.T., H.L., P.G., Z.X., W.T., D.A., E.S.-O., J.R.M., N.L., E.N.O.), University of Texas Southwestern Medical Center, Dallas.ORCID 0000-0001-9358-1630
John R McAnallyDepartment of Molecular Biology (T.T., H.L., P.G., Z.X., W.T., D.A., E.S.-O., J.R.M., N.L., E.N.O.), University of Texas Southwestern Medical Center, Dallas.ORCID 0000-0001-6938-2703
Lei GuoQuantitative Biomedical Research Center, Peter O'Donnell Jr. School of Public Health, (L.G., L.X.), University of Texas Southwestern Medical Center, Dallas.
Lin XuQuantitative Biomedical Research Center, Peter O'Donnell Jr. School of Public Health, (L.G., L.X.), University of Texas Southwestern Medical Center, Dallas.ORCID 0000-0001-5815-4457
Peifeng RuanDepartment of Health Data Science and Biostatistics, Peter O'Donnell Jr. School of Public Health (P.R.), University of Texas Southwestern Medical Center, Dallas.
Ning LiuDepartment of Molecular Biology (T.T., H.L., P.G., Z.X., W.T., D.A., E.S.-O., J.R.M., N.L., E.N.O.), University of Texas Southwestern Medical Center, Dallas.ORCID 0000-0003-0257-1889
Eric N OlsonDepartment of Molecular Biology (T.T., H.L., P.G., Z.X., W.T., D.A., E.S.-O., J.R.M., N.L., E.N.O.), University of Texas Southwestern Medical Center, Dallas.ORCID 0000-0003-1151-8262
Funding
T-Cell-Mediated Inflammatory Response in Neonatal Heart RegenerationP01HL160488 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI Hesham Sadek · 2023 to 2026
$10.2M
Training CoreP50HD087351 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI BASSEL-DUBY, RHONDA, IANNACCONE, SUSAN T · 2020 to 2024
$8.0M
UT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Jeffrey M Zigman · 2022 to 2026
$7.4M
ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale ModelingR01GM129325 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2018 to 2025
$5.2M
Transcriptional Control of Neonatal Heart RegenerationR01HL157281 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI BASSEL-DUBY, RHONDA, OLSON, ERIC N · 2022 to 2025
backgroundThe prevalence of heart failure is increasing globally, with poor prognosis, highlighting the need for novel therapeutic strategies. PKCα (protein kinase C alpha), encoded by
methodsWe generated mice harboring a phospho-resistant PKCα (T497A) mutation in the germline using CRISPR-Cas9 (clustered regularly interspaced short palindromic repeats/clustered regularly interspaced short palindromic repeat-associated 9)-mediated homology-directed repair. To assess the clinical feasibility of postnatal genome editing, we used CRISPR-Cas9 adenine base editing delivered by adeno-associated virus 9 to introduce the T497A substitution into the
resultsThe T497A mutation in PKCα prevented its subsequent phosphorylation and led to PKCα protein degradation. Four weeks after transverse aortic constriction surgery, wild-type mice showed impaired cardiac function, cardiac remodeling, and increased lung weight. In contrast, PKCα phospho-resistant mice showed protection against heart failure-related aberrant changes in cardiac hypertrophy, fibrosis, and cardiac gene expression. Mice administered with adeno-associated virus 9 base editors to prevent T497 phosphorylation exhibited similar cardioprotective effects. In vitro, PKCα-edited induced pluripotent stem cell-derived cardiomyocytes were protected from AngII-induced impairments in contractility and Ca
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Ablation of PKCα Phosphorylation by CRISPR-Cas9 Base Editing Rescues Heart Failure. · full record | OpenQuestion