ArticleFrontiers in cellular neuroscience2026
Enhancing oligodendrocytes generation and myelin renewal by vitamin C mitigate Parkinson-relevant phenotypes in a murine model of Parkinson's disease.
Article in Frontiers in cellular neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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6 authors.
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Abstract
Parkinson's disease (PD) is a major neurodegenerative disease with an increasing global prevalence. In addition to progressive dopaminergic neurons degeneration, emerging evidence implicates oligodendrocyte (OL) dysfunction and impaired myelin also contribute to PD pathogenesis. Here, we observed a significant reduction of myelin basic protein (MBP) and the number of OLs in the MPTP-induced chronic PD mouse model. Vitamin C (VC) has been reported to promote myelin regeneration in the demyelination mouse model, though its underlying mechanism remains unclear. Therefore, this study investigated the therapeutic effects of VC in the mouse model of PD by the enhancement of OPC-to-oligodendrocyte differentiation and myelin renewal. Using
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