Quantitative Electroencephalographic (qEEG) Characterisation and Biomarker Identification of Generalised Paediatric Seizure Using Spectral Features.

Background: Epilepsy possesses significant long-term health sequelae and potential morbidity among children globally. A diagnosis of seizures can often be challenging in the paediatric population owing to seizure mimics and absence of classical features in clinical as well as electroencephalographic (EEG) presentations. Purpose: The objective of the study is to explore potential EEG biomarkers using quantitative analysis of conventional EEG records of subjects with seizure in paediatric populations. Method: 66 subjects with generalised seizures in the age group of 2-15 years had been recruited along with an equal number of age-matched healthy control subjects. Readings obtained from a 32-channel EEG were recorded along with the demographic details of the subjects. Using the Fast Fourier Transform (FFT) in the MATLAB environment, quantitative spectral features were extracted and compared between the groups and within the group to explore EEG markers related to the generalised seizures in the study population. Results: The case group showed significantly higher alpha power in both left (17.86 vs 15.06 µV Conclusion: The study reveals a complex pattern of characteristic quantitative electroencephalographic (qEEG) alterations in the paediatric seizure population suggestive of significant neurophysiological implications, including alterations in arousal, attention and inhibitory control mechanisms and the features may be of some value in objective seizure assessment using EEG.