ArticleTurkish journal of physical medicine and rehabilitation2025
The effects of weekly or daily oral cholecalciferol use on muscle strength, muscle thickness, and functional independence in patients with spinal cord injury.
Article in Turkish journal of physical medicine and rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: This study aims to evaluate the effects of vitamin D supplementation at different doses and dose intervals on upper extremity muscle strength, muscle thickness, and functional independence of patients with paraplegic spinal cord injury (SCI). Patients and methods: This prospective controlled clinical trial included 64 paraplegic patients (45 males, 19 females; mean age: 39.7±11.5 years; range, 18 to 64 years) with serum 25-hydroxyvitamin D (25[OH]D) levels <20 ng/mL between June 2020 and June 2021. Participants were divided into three groups: control (n=20), daily supplementation with 6000 IU cholecalciferol (n=23), and weekly supplementation with 50,000 IU cholecalciferol (n=21) for eight weeks. Hand grip strength was assessed with a dynamometer, muscle thickness was measured using ultrasonography, and functional independence was evaluated with the Spinal Cord Independence Measure III. Results: Serum 25(OH)D levels significantly increased in both supplementation groups compared to baseline (p=0.001). Nondominant hand grip strength significantly improved in both groups (daily, p=0.025; weekly, p=0.038). Muscle thickness of the biceps brachii significantly increased in the daily group (p<0.05), while triceps brachii thickness significantly improved in both groups (p<0.001). Spinal Cord Independence Measure III scores, encompassing self-care, respiratory-sphincter control, and mobility, showed significant improvements in the supplementation groups (p<0.05), but no changes were observed in the control group. No significant differences were found between daily and weekly supplementation regimens. Conclusion: Vitamin D supplementation, whether daily or weekly, improved muscle performance and functional independence in individuals with SCI. While these findings support the inclusion of vitamin D replacement in rehabilitation programs, larger and longerterm studies are needed to confirm the benefits.
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