Evidence map›Paper›PMID 41717216›Full record

ArticleJournal of translational autoimmunity2026

Biopsy-proven myocarditis: peripheral immunophenotypes correlate with histology, etiology, immunosuppressive therapy.

Cristina Vicenzetto, Andrea Silvio Giordani, Anna Baritussio, Federico Scognamiglio, Maria Grazia Peloso-Cattini, Elena Pontara, Elisa Bison, Gloria Brigiari, Giuseppe Tarantini, Massimo Napodano and 8 more

Abstract read
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In one paragraph

Article in Journal of translational autoimmunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

18 authors.

Cristina VicenzettoCardiology, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy.
Andrea Silvio GiordaniCardiology, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy.
Anna BaritussioCardiology, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy.
Federico ScognamiglioCardiology, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy.
Maria Grazia Peloso-CattiniCardiology, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy.
Elena PontaraCardiology, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy.
Elisa BisonCardiology, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy.
Gloria BrigiariUnit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy.
Giuseppe TarantiniCardiology, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy.
Massimo NapodanoCardiology, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy.
Giuseppe ToscanoCardiac Surgery, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy.
Dario GregoriUnit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy.
Elisa CarturanCardiovascular Pathology, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy.
Monica De GaspariCardiovascular Pathology, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy.
Stefania RizzoCardiovascular Pathology, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy.
Cristina BassoCardiovascular Pathology, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy.
Renzo MarcolongoCardiology, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy.
Alida Linda Patrizia CaforioCardiology, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Myocarditis is an inflammatory disease of the myocardium with infectious or immune-mediated/autoimmune etiology; etiology diagnosis relays on endomyocardial biopsy (EMB). High titre serum anti-heart autoantibodies (AHA) define severe autoimmune forms. In autoimmune myocarditis immunosuppression (IS) may be required to prevent progression to dilated cardiomyopathy, heart transplant or death, but it is not always effective. This study aimed to identify non-invasive cellular biomarkers of etiology and response to IS in biopsy-proven myocarditis peripheral blood. Methods: Fifty-eight EMB-proven myocarditis patients out of IS were enrolled and compared with 9 healthy controls and 20 EMB-proven myocarditis on IS. Cells distribution was evaluated by flow cytometry; results were related to clinical, EMB and AHA findings. Results: Compared to healthy controls, plasmacytoid dendritic cells percentage was reduced in autoimmune (p = 0.017), in lymphocytic (p = 0.012) myocarditis patients, in those without extra-cardiac autoimmune diseases (AD, p = 0.01), and in myocarditis not on IS (p = 0.003). Viral myocarditis had higher CD62L+/CD56+ NK cells percentage (p = 0.001) and CCR2 over-expression in intermediate monocytes when compared with autoimmune myocarditis (p = 0.013). Autoimmune myocarditis was characterized by higher Th1/Th2 (p = 0.004) and Th17/Treg ratio (p = 0.008), Th1 (p = 0.028) and Th17 lymphocytes (p = 0.017) percentage vs. healthy controls. A reduction of Treg cells percentage was specific for autoimmune lymphocytic (p = 0.047 vs healthy controls), for AHA-positive myocarditis (p = 0.03 vs healthy controls) and for myocarditis unresponsive to IS (p = 0.036). Conclusions: Biopsy-proven myocarditis patients showed distinct peripheral immunophenotypes of either innate or adaptive immune cells according to different histology, etiology and response to IS, unveiling potential novel non-invasive etiological biomarkers for myocarditis.

Indexed as

BiomarkerCellular immunityEndomyocardial biopsyImmunosuppressionMyocarditis

Identifiers

PMID41717216
PMCPMC12914123

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