ArticleBrain communications2026
Data-driven probabilistic mapping of the spatial and molecular landscape of glioma.
Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- An MRI Atlas of Regional Brain Vulnerability to Metastatic Disease.medRxiv : the preprint server for health sciences · 2026Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding the spatial distribution of gliomas in the brain and their molecular subtypes can aid in the diagnosis and development of targeted therapies. This study aims to create probabilistic radiologic maps of glioma locations using large MRI datasets and the most recent consensus brain tumour classification. Neuroimaging data from multiple databases were analysed. Patients included had MRI T1 images and validated tumour segmentations. Probabilistic tumour maps were generated whereby binary tumour masks were aligned to a standard brain template and aggregated to compute voxel-wise frequency maps of glioma occurrence detailing glioma volume, molecular subtype, age, sex and overall survival with tumour location. The study included 2164 patients with gliomas. Key findings include distinct spatial patterns associated with glioma size and molecular subtype: smaller tumours favoured the left temporal region, medium-sized tumours the medial frontoparietal and bilateral temporal regions and larger tumours the frontotemporoparietal regions, predominantly on the right. Isocitrate dehydrogenase (IDH)-wild-type tumours were more common in medial parietotemporal regions, while IDH-mutant tumours were preferentially found in frontotemporal regions. Younger patients had more frontal tumours, while older patients had higher parieto-occipital tumour burdens. Tumours in medial structures and parietal lobes were linked to lower survival, whereas right temporal tumours were associated with higher rates of survival. These findings likely correlate with IDH mutation status. Leveraging eight glioma databases, probabilistic tumour maps revealed significant relationships between brain regions, molecular subtypes and clinical outcomes. These findings could be used in clinical decision-making and offer insights into glioma pathogenesis and treatment of patients impacted by this disease.
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