ArticleFrontiers in plant science2026
Stage-specific metabolic divergence in flavonoid biosynthesis correlates with embryogenic capacity in rubber tree (
Article in Frontiers in plant science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Somatic embryogenesis (SE) is an essential propagation technology for Methods: To elucidate the metabolic basis of this variation, we conducted integrated metabolomic and transcriptomic analyses across four SE developmental stages in a high-embryogenic (HE) and a low-embryogenic (LE) genotype, including explants, induced callus, non-embryogenic / embryogenic callus, and cotyledonary embryos (HE-specific). Results: A total of 1,383 metabolites belonging to 11 major classes were identified, with flavonoids, phenolic acids, and amino acids being the predominant groups. PCA and hierarchical clustering revealed that metabolic variation was driven primarily by developmental stage rather than genotype. Differential metabolite profiling revealed strong stage specificity, with the callus-to-differentiation transition (LE-C vs. HE-EC) exhibiting the greatest metabolic divergence between genotypes. KEGG enrichment consistently highlighted flavonoid biosynthesis as a key differentiating pathway. Comparative analyses revealed a conserved-to-divergent pattern of metabolic regulation. During the explant-to-callus transition, both genotypes exhibited highly conserved flavonoid biosynthesis responses, with 67.5% of genes and 85.7% of metabolites showing concordant regulation (either both up-regulated or both down-regulated). In contrast, during the callus-to-differentiation transition, pronounced metabolic divergence emerged, with only 37.5% of genes and 6.7% of metabolites showing concordant regulation, and 11 flavonoid-related genes displaying opposite regulatory directions between genotypes. Notably, the HE genotype exhibited coordinated repression of Discussion: Our results provide comprehensive metabolomic evidence for stage-dependent metabolic reprogramming during SE in
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.