Evidence map›Paper›PMID 41717095›Full record

ReviewClinical and translational radiation oncology2026

Effect of dose escalation in neoadjuvant chemoradiotherapy of locally advanced rectal cancer on clinical and pathologic Response: A Systematic review and

Kasra Kolahdouzan, Sepehr Nayebi Rad, Reza Ghalehtaki, Romina Abyaneh, Forouzan Nourbakhsh, Ehsan Saraee

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical and translational radiation oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kasra KolahdouzanDepartment of Radiation Oncology, Imam Khomeini Hospital Complex, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Sepehr Nayebi RadSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Reza GhalehtakiDepartment of Radiation Oncology, Imam Khomeini Hospital Complex, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Romina AbyanehRadiation Oncology Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran.
Forouzan NourbakhshDepartment of Radiation Oncology, Imam Khomeini Hospital Complex, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Ehsan SaraeeDepartment of Radiation Oncology, Imam Khomeini Hospital Complex, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Management of locally advanced rectal cancer (LARC) increasingly highlights necessity of organ functionality preservation, with the achievement of a complete clinical or pathological response (CR) regarded as a fundamental treatment target. While established concurrent chemoradiation (CRT) is effective, it often results in only modest complete response rates, thus prompting exploration into the possible benefits of raising radiation dosages to boost clinical results. This

Indexed as

Complete responseDose escalationNeoadjuvantchemoradiotherapyOrgan preservationRectal cancerToxicity

Identifiers

PMID41717095
PMCPMC12915287

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.