Evidence map›Paper›PMID 41717087›Full record

ArticleFrontiers in microbiology2025

Emergence and characterization of a novel ST627-KL8 carbapenem-resistant

Xiaoxiao Pang, Guoxin Xu, Yu Zheng, Chao Ding, Wei Zhang, Hong Du, Long Chen

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Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Xiaoxiao Pang *Department of Clinical Laboratory, The First People's Hospital of Zhangjiagang City, Zhangjiagang Hospital Affiliated to Soochow University, Zhangjiagang, China.
Guoxin Xu *Department of Clinical Laboratory, The First People's Hospital of Zhangjiagang City, Zhangjiagang Hospital Affiliated to Soochow University, Zhangjiagang, China.
Yu ZhengDepartment of Clinical Laboratory, The First People's Hospital of Zhangjiagang City, Zhangjiagang Hospital Affiliated to Soochow University, Zhangjiagang, China.
Chao DingDepartment of Clinical Laboratory, The First People's Hospital of Zhangjiagang City, Zhangjiagang Hospital Affiliated to Soochow University, Zhangjiagang, China.
Wei ZhangCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Hong DuDepartment of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Long ChenDepartment of Clinical Laboratory, The First People's Hospital of Zhangjiagang City, Zhangjiagang Hospital Affiliated to Soochow University, Zhangjiagang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Carbapenem-resistant Methods: Three isolates (ZJG29565, ZJG30140, and ZJG30146) were obtained from three patients in the ICU and subjected to antimicrobial susceptibility testing. Whole-genome sequencing (WGS) was performed to determine genomic characteristics, phylogenetic relationships, and plasmid content, followed by assessments of mucoviscosity, capsule quantification, serum resistance, and bacterial virulence using a Results: SNP analysis (≤ 5 SNPs) confirmed clonal transmission within the ICU. Phylogenetic analysis placed ST627-KL8 as a distinct lineage closely related to ST14. All isolates carried an IncFII Discussion: This study identified a novel ST627-KL8 CRKP clone with intermediate virulence, consistent with its reduced capsule phenotype and lack of classical hypervirulence genes. These features, together with the subtle clinical presentations, may contribute to reduced clinical vigilance and delayed optimization of antimicrobial therapy. Importantly, ST627-KL8 CRKP carried the IncFII

Indexed as

carbapenem-resistanceIncFIIK34 plasmidKlebsiella pneumoniaenosocomial infectionST627-KL8 type

Identifiers

PMID41717087
PMCPMC12915689

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