Evidence map›Paper›PMID 41717006›Full record

ArticleiScience2026

Multiparametric imaging of spatio-temporal cAMP signaling, transmembrane potential, and intracellular calcium in the intact heart.

I-Ju E Lee, Jessica L Caldwell, Lilian R Mott, Jorge L Gonzalez, Lianguo Wang, Crystal M Ripplinger

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

I-Ju E LeeDepartment of Biomedical Engineering, University of California, Davis, Davis, CA, USA.
Jessica L CaldwellDepartment of Pharmacology, University of California, Davis, Davis, CA, USA.
Lilian R MottDepartment of Pharmacology, University of California, Davis, Davis, CA, USA.
Jorge L GonzalezDepartment of Biomedical Engineering, University of California, Davis, Davis, CA, USA.
Lianguo WangDepartment of Pharmacology, University of California, Davis, Davis, CA, USA.
Crystal M RipplingerDepartment of Biomedical Engineering, University of California, Davis, Davis, CA, USA.

Funding

The Role of Adrenergic Stimulation in ArrhythmogenesisR01HL111600 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Crystal May Ripplinger · 2012 to 2026
$7.1M
Sex differences in cardiac autonomic remodeling after myocardial infarctionR01HL170626 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Crystal May Ripplinger, Marmar Vaseghi · 2024 to 2026
$2.1M
Sex-dependent regulation of cardiac cAMP, ECC, and arrhythmia by phosphodiesterasesR01HL179122 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Crystal May Ripplinger, YANG Kevin XIANG · 2025 to 2026
$1.3M
NHLBI NIH HHS R01 HL111600NHLBI NIH HHS R01 HL170626NHLBI NIH HHS R01 HL179122
6 · The paper itself

Abstract

The spatiotemporal dynamics of intracellular second messengers and signaling molecules, including cyclic adenosine monophosphate (cAMP), have been studied extensively in isolated cardiomyocytes using Förster resonance energy transfer (FRET)-based reporters. However, approaches for linking cellular signaling to tissue-level function are limited. Here, we present a multiparametric imaging system that simultaneously records four wavelengths to visualize cAMP activity alongside real-time transmembrane potential and intracellular Ca

Indexed as

bioengineeringexperimental models in systems biologymolecular physiology

Identifiers

PMID41717006
PMCPMC12915281

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.