Evidence map›Paper›PMID 41716932›Full record

ArticleEuropean heart journal. Digital health2026

Validation and longitudinal trajectory analysis of an AI-based ECG model for aortic stenosis: from community screening to pre-TAVR risk stratification.

Matthew W Segar, Kaleb D Lambeth, Alexander Postalian, Stephanie Coulter, Jasen Gilge, Naveed Razvi, Mohammad Saeed, Robert D Paisley, Ambarish Pandey, Mehdi Razavi

Abstract read
In one paragraph

Article in European heart journal. Digital health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Matthew W SegarDepartment of Cardiology, Texas Heart Institute, 6770 Bertner Ave, Houston, TX 77030, USA.ORCID https://orcid.org/0000-0001-6100-0897
Kaleb D LambethDepartment of Cardiology, Texas Heart Institute, 6770 Bertner Ave, Houston, TX 77030, USA.
Alexander PostalianDepartment of Cardiology, Texas Heart Institute, 6770 Bertner Ave, Houston, TX 77030, USA.
Stephanie CoulterDepartment of Cardiology, Texas Heart Institute, 6770 Bertner Ave, Houston, TX 77030, USA.
Jasen GilgeDepartment of Cardiac Electrophysiology, Ascension St. Vincent, Indianapolis, IN, USA.ORCID https://orcid.org/0000-0001-9370-4370
Naveed RazviDepartment of Cardiology, Ipswich Hospital, Ipswich, United Kingdom.
Mohammad SaeedDepartment of Cardiology, Texas Heart Institute, 6770 Bertner Ave, Houston, TX 77030, USA.
Robert D PaisleyDepartment of Cardiology, Texas Heart Institute, 6770 Bertner Ave, Houston, TX 77030, USA.
Ambarish PandeyDivision of Cardiology, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.
Mehdi RazaviDepartment of Cardiology, Texas Heart Institute, 6770 Bertner Ave, Houston, TX 77030, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Early aortic stenosis (AS) detection remains challenging, with many patients presenting late when left ventricular dysfunction may be irreversible. We evaluated whether longitudinal AI-enhanced ECG patterns can predict outcomes years before intervention and assessed the community screening potential of the AK-AVS model. Methods and results: We conducted two complementary analyses: (1) community validation of the AK-AVS model in 3632 cardiovascular disease-free ARIC participants, and (2) longitudinal trajectory analysis of 7860 ECGs from 2040 TAVR recipients collected up to 10 years pre-procedure. Unsupervised clustering identified distinct AK-AVS trajectories, with mortality associations assessed using Cox regression and net reclassification improvement. In community screening ( Conclusion: Longitudinal AI-ECG trajectory patterns detect disease progression up to 4.5 years before TAVR and enhance mortality prediction beyond traditional risk scores. Community validation shows potential screening utility with 'false-positives' identifying future risk.

Indexed as

Aortic stenosisArtificial intelligenceCommunity screeningElectrocardiographyRisk prediction

Identifiers

PMID41716932
PMCPMC12912914

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.