Evidence map›Paper›PMID 41716909›Full record

ArticleChem2025

An unconventional photochemical tetrahydroisoquinoline synthesis from sulfonylimines and alkenes.

Wang Wang, Bodi Zhao, Xiaotian Qi, M Kevin Brown

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Wang WangDepartment of Chemistry, Indiana University, Bloomington, IN, USA.
Bodi ZhaoState Key Laboratory of Power Grid Environmental Protection, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, Hubei, P.R. China.
Xiaotian QiState Key Laboratory of Power Grid Environmental Protection, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, Hubei, P.R. China.
M Kevin BrownDepartment of Chemistry, Indiana University, Bloomington, IN, USA.

Funding

Methods and Strategies for Chemical SynthesisR35GM131755 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI Michael Kevin Brown · 2019 to 2026
$4.0M
NIGMS NIH HHS R35 GM131755
6 · The paper itself

Abstract

Tetrahydroisoquinolines (THIQ) are prevalent scaffolds found in natural products and pharmaceutical agents. Therefore, new methods for the synthesis of this motif, especially with unique stereochemistry or substitution patterns, are highly desirable. Herein, a new disconnection is demonstrated that combines sulfonylimines and alkenes. The convergent process operates by photoinduced energy transfer. High selectivities for the formation of the anti-isomer were observed. In addition, through the use of highly substituted alkenes, the synthesis of quaternary carbon containing tetrahydroisoquinolines can be achieved. Finally, mechanistic studies are included, revealing that the high selectivity observed is due to subtle variation of the highest occupied molecular orbital (HOMO) energies.

Identifiers

PMID41716909
PMCPMC12916132

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.