Evidence map›Paper›PMID 41716904›Full record

ArticleJournal of liver transplantation2026

Expanding the donor pool: Outcomes of liver transplantation using grafts with ≥50% macrosteatosis.

Kasra Shirini, Shani S Kamberi, Srinivasan Muthukrishnan, Omar Alattar, Ruchin Patel, Francheska Nieves, Massimo Arcerito, Josue Alvarez-Casas, Saad Malik, Kirti Shetty and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of liver transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kasra ShiriniDivision of Transplant Surgery, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-4104-7633
Shani S KamberiDivision of Transplant Surgery, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Srinivasan MuthukrishnanDivision of Transplant Surgery, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-6962-1559
Omar AlattarDivision of Transplant Surgery, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-2249-123X
Ruchin PatelDivision of Transplant Surgery, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Francheska NievesDivision of Transplant Surgery, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Massimo ArceritoDivision of Transplant Surgery, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-6906-9856
Josue Alvarez-CasasDivision of Transplant Surgery, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Saad MalikDivision of Transplant Surgery, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Kirti ShettyDivision of Transplant Surgery, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Daniel G MalufDivision of Transplant Surgery, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-5921-4834
Chandra BhatiDivision of Transplant Surgery, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Raphael P H MeierDivision of Transplant Surgery, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-9050-0436

Funding

Pathway Specific Functional Biomarkers for the Early Detection of Liver CancerU01CA230690 · NCI · GEORGE WASHINGTON UNIVERSITY · PI MISHRA, LOPA, SHETTY, KIRTI · 2018 to 2022
$3.4M
NCI NIH HHS U01 CA230690
6 · The paper itself

Abstract

Liver grafts with over 50% macrosteatosis are often deemed marginal, but organ shortages necessitate exploring their use. We conducted five transplants with deceased donor grafts containing 50%-90% macrosteatosis, ensuring donor age <55 years, CIT ≤6 hours, and recipient laboratory MELD score ≤30. Two patients required reoperations due to thrombotic complications (acute HAT and PVT), and hospital stay ranged from 6 to 26 days. All patients survived beyond one year with functioning grafts. These findings suggest the feasibility of using high-macrosteatosis grafts in intermediate- to low-laboratory-MELD recipients, albeit with potential thrombotic risks.

Indexed as

Liver graftLiver macrosteatosisLiver transplantationTransplantation

Identifiers

PMID41716904
PMCPMC12915996

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.