Evidence map›Paper›PMID 41716896›Full record

ArticleInfection and drug resistance2026

Comparative in vitro Activity and Clinical Outcomes of Eravacycline, Tigecycline, and Omadacycline Against Carbapenem-Resistant

Diandian Chen, He Lan, Wenshuo Yang, Dequan Tian, Yunyi Liu, Leyang Ju, Qiao Song, Rong Min, Yan Wang, Ying Li and 2 more

Erratum issuedAbstract read
In one paragraph

Article in Infection and drug resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Diandian Chen *Department of Clinical Laboratory, Xuanwu Hospital Capital Medical University, National Gerontic Disease Clinical Research Center, Beijing, 100053, People's Republic of China.
He Lan *Department of Clinical Laboratory, Xuanwu Hospital Capital Medical University, National Gerontic Disease Clinical Research Center, Beijing, 100053, People's Republic of China.
Wenshuo Yang *Department of Clinical Laboratory, Xuanwu Hospital Capital Medical University, National Gerontic Disease Clinical Research Center, Beijing, 100053, People's Republic of China.
Dequan TianDepartment of Clinical Laboratory, Xuanwu Hospital Capital Medical University, National Gerontic Disease Clinical Research Center, Beijing, 100053, People's Republic of China.
Yunyi LiuDepartment of Clinical Laboratory, Xuanwu Hospital Capital Medical University, National Gerontic Disease Clinical Research Center, Beijing, 100053, People's Republic of China.
Leyang JuDepartment of Clinical Laboratory, Xuanwu Hospital Capital Medical University, National Gerontic Disease Clinical Research Center, Beijing, 100053, People's Republic of China.
Qiao SongDepartment of Clinical Laboratory, Xuanwu Hospital Capital Medical University, National Gerontic Disease Clinical Research Center, Beijing, 100053, People's Republic of China.
Rong MinDepartment of Clinical Laboratory, Xuanwu Hospital Capital Medical University, National Gerontic Disease Clinical Research Center, Beijing, 100053, People's Republic of China.ORCID 0000-0003-0022-3565
Yan WangDepartment of Clinical Laboratory, Xuanwu Hospital Capital Medical University, National Gerontic Disease Clinical Research Center, Beijing, 100053, People's Republic of China.
Ying LiDepartment of Clinical Laboratory, Xuanwu Hospital Capital Medical University, National Gerontic Disease Clinical Research Center, Beijing, 100053, People's Republic of China.
Peichang WangDepartment of Clinical Laboratory, Xuanwu Hospital Capital Medical University, National Gerontic Disease Clinical Research Center, Beijing, 100053, People's Republic of China.
Jingrong CaoDepartment of Clinical Laboratory, Xuanwu Hospital Capital Medical University, National Gerontic Disease Clinical Research Center, Beijing, 100053, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Carbapenem-resistant Patients and Methods: A total of 106 CRKP and 117 CRAB non-duplicate clinical isolates were collected from Xuanwu Hospital (Beijing) between December 2024 and June 2025. Minimum inhibitory concentrations (MICs) were determined using broth microdilution (CLSI M07 guidelines). Time-kill assays (0-48 h) were used to evaluate bactericidal activity, and clinical outcomes were analyzed in patients treated with TGC or ERV. Results: ERV demonstrated superior in vitro activity: its MIC Conclusion: Current evidence indicates that ERV exhibits strong in vitro bactericidal activity and demonstrates more favorable clinical efficacy comparable to that of TGC against CRKP and CRAB infections, as observed in our retrospective clinical cohort.

Indexed as

broth microdilutioncarbapenem-resistant Acinetobacter baumanniicarbapenem-resistant Klebsiella pneumoniaetetracycline-class antibioticstime-kill assays

Identifiers

PMID41716896
PMCPMC12915463

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.