ArticleInfection and drug resistance2026
Comparative Genomic Analysis of
Article in Infection and drug resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To characterize the genomic features of Patients and Methods: Three CAP isolates collected in China underwent antimicrobial susceptibility testing and whole-genome sequencing. Comparative genomic analyses were performed against 84 complete HAP-associated genomes retrieved from NCBI RefSeq (accessed in December 2023), including core genome SNP phylogeny, profiling of antimicrobial resistance (AMR) determinants, virulence genes, and pangenome analysis to identify CAP-specific genes. Results: The three CAP cases presented with severe pneumonia (including septic shock), with one fatality; however, all CAP isolates remained susceptible to the most commonly used antipseudomonal agents. CAP genomes were 6.5-7.1 Mb (GC 65.76-66.41%) and contained 5908-6633 predicted coding sequences. Core-SNP phylogeny showed clustering of the three CAP isolates. Compared with HAP genomes, CAP isolates harbored fewer acquired AMR genes and fewer resistance-associated mutations. Virulence profiling identified a subset of virulence genes absent from all CAP genomes (n = 40), largely annotated as immune modulation and including loci consistent with highly variable surface polysaccharide regions, together with several genes annotated to biofilm-related functions and effector delivery systems. Major type III secretion system effector profiles differed across CAP isolates ( Conclusion: CAP-associated
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.