Evidence map›Paper›PMID 41716876›Full record

ArticleBrain & spine2026

Risk factor analysis of growing unruptured intracranial aneurysms: A single center cohort study.

Francis J Kissling, Johannes Goldberg, Bettina L Serrallach, Michael Murek, Tomas Dobrocky, Eike I Piechowiak, Jan Gralla, Andreas Raabe, David Bervini

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain & spine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Francis J KisslingUniversity of Bern, Bern, Switzerland.
Johannes GoldbergDepartment of Neurosurgery, Inselspital, Bern University Hospital, Bern, Switzerland.
Bettina L SerrallachDepartment of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, Bern, Switzerland.
Michael MurekDepartment of Neurosurgery, Inselspital, Bern University Hospital, Bern, Switzerland.
Tomas DobrockyUniversity of Bern, Bern, Switzerland.
Eike I PiechowiakUniversity of Bern, Bern, Switzerland.
Jan GrallaUniversity of Bern, Bern, Switzerland.
Andreas RaabeUniversity of Bern, Bern, Switzerland.
David BerviniUniversity of Bern, Bern, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Intradural unruptured intracranial aneurysms (UIA) can rupture and lead to subarachnoid hemorrhage. Previous studies suggest aneurysm growth being a strong risk factor for rupture. The natural history and the individual risk of growth of aneurysms remain controversial. Research question: To analyze the time to growth and identify risk factors associated with growth of UIAs. Materials and methods: Prospectively collected data of 588 patients with a total of 858 UIAs followed up by imaging were analyzed. Patients and aneurysms were categorized in a growing or a stable cohort. Logistic and survival analyses were used to assess potential factors associated with UIA growth. Results: During a median follow-up of 3.4 years (IQR 1.3 - 6.6 years), 112 (13.1%) out of the 858 UIAs showed an increase in size or a change of morphology. Posterior circulation UIAs (OR 2.01 (1.15 - 3.52), Discussion and conclusion: UIA location in the posterior circulation, a larger size at diagnosis and the presence of arterial hypertension are significant risk factors associated with UIA growth.

Indexed as

Aneurysm growthIntracranial aneurysmRisk factorsSurvival analysisUIA

Identifiers

PMID41716876
PMCPMC12914676

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