Evidence map›Paper›PMID 41716769›Full record

ArticleCurrent opinion in physiology2025

Current diagnostic modalities for detecting myocardial relaxation function in diabetes-associated heart failure or heart failure with preserved ejection fraction.

Dhrubo Ahmad, Taslima Akter Shila, Yuhui Yang, Huilan Tan, Yajing Wang

Abstract read
In one paragraph

Article in Current opinion in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dhrubo AhmadDepartment of Biomedical Engineering, University of Alabama at Birmingham, AL.
Taslima Akter ShilaDepartment of Biomedical Engineering, University of Alabama at Birmingham, AL.
Yuhui YangDepartment of Biomedical Engineering, University of Alabama at Birmingham, AL.
Huilan TanDepartment of Biomedical Engineering, University of Alabama at Birmingham, AL.
Yajing WangDepartment of Biomedical Engineering, University of Alabama at Birmingham, AL.

Funding

Targeting Adiponectin for Cardioprotection in the Ischemic HeartR01HL096686 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI MA, XIN-LIANG, WANG, YAJING · 2010 to 2024
$4.7M
Cav-3 in Diabetic Myocardial Injury Following Ischemia/ReperfusionR01HL123404 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI MA, XIN-LIANG · 2015 to 2023
$2.7M
Dysregulated Adiponectin Transmembrane Signaling in Diabetic CoronaryVascular Injury and Heart FailureR01HL157495 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WANG, YAJING · 2022 to 2025
$2.3M
Critical Role of Small Extracellular Vesicles in Diabetic Coronary VascularDysfunction and Diabetic Ischemic Heart Failure effortsR01HL158612 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WANG, YAJING · 2021 to 2024
$1.5M
Improving Cardiac Microenvironment as a Novel Strategy against Diabetic Ischemic Heart FailureR01HL173090 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Yajing Wang, Jianyi Zhang · 2025 to 2026
$1.3M
Cav-3 in Diabetic Myocardial Injury Following Ischemia/ReperfusionR56HL123404 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI MA, XIN-LIANG · 2014 to 2014
$388k
American Heart Association-American Stroke Association 24TPA1293530NHLBI NIH HHS R01 HL096686NHLBI NIH HHS R01 HL123404NHLBI NIH HHS R01 HL157495NHLBI NIH HHS R01 HL158612NHLBI NIH HHS R01 HL173090NHLBI NIH HHS R56 HL123404
6 · The paper itself

Abstract

Impaired cardiac relaxation, or diastolic dysfunction, is a key contributor to heart failure in diabetic patients, making early detection critical for preventing disease progression. This review explores current diagnostic modalities for assessing myocardial relaxation function in diabetes-associated HFpEF, including imaging techniques, biomarker analysis, and emerging chip-based technologies. We highlight advancements in echocardiography, cardiac MRI, molecular diagnostics, and innovative microfluidic and biosensor-based devices that offer real-time monitoring of myocardial relaxation dynamics. Integrating these diverse modalities holds promise for enhancing early diagnosis and enabling personalized therapeutic approaches to improve patient outcomes.

Indexed as

AIbiomarkerDiabetic Heart Failurediastolic Dysfunctionimagingmyocardial Relaxationsensors

Identifiers

PMID41716769
PMCPMC12915894

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.