Evidence map›Paper›PMID 41716736›Full record

ArticleKidney international reports2026

Kidney Outcomes in ANCA-Glomerulonephritis According to Induction Immunosuppression and Histopathology.

Martina Uzzo, Federica Mescia, Jennifer Scott, Jennifer O'Brien, Kresimir Galesic, Simonetta Genovesi, Giorgio Trivioli, Marco Allinovi, Iva Gunnarsson, Anna Juto and 15 more

Abstract read
In one paragraph

Article in Kidney international reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors.

Martina UzzoDepartment of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Federica MesciaNephrology Unit, University of Brescia and ASST Spedali Civili di Brescia, Brescia, Italy.
Jennifer ScottTrinity Kidney Centre, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
Jennifer O'BrienRenal and Transplant Centre, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, UK.
Kresimir GalesicDepartment of Nephrology and Dialysis, Dubrava University Hospital, Zagreb, Croatia.
Simonetta GenovesiSchool of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Giorgio TrivioliDepartment of Medicine, University of Cambridge, UK.
Marco AllinoviNephrology, Dialysis and Transplantation Unit, Careggi University Hospital, Florence, Italy.
Iva GunnarssonDepartment of Medicine Solna, Division of Rheumatology, Karolinska Institutet, Rheumathology Karolinska University Hospital, Stockholm, Sweden.
Anna JutoDepartment of Medicine Solna, Division of Rheumatology, Karolinska Institutet, Rheumathology Karolinska University Hospital, Stockholm, Sweden.
Robert HallTrinity Kidney Centre, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
Ingeborg BajemaDepartment of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Silke R BrixKidney, Transplantation and Urology Unit, Manchester University Hospitals NHS Foundation Trust.
Vincenzo L'ImperioSchool of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Andreas KronbichlerDepartment of Internal Medicine IV (Nephrology and Hypertension), Medical University Innsbruck, Innsbruck, Austria.
Annette BruchfeldDepartment of Health, Medicine and Caring Sciences, Linköping University Hospital, Linköping, Sweden.
Gaetano La MannaNephrology Dialysis and Kidney Transplant Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Mario CozzolinoDepartment of Health Sciences, University of Milan, and Kidney Division, ASST Santi Paolo e Carlo, Milan, Italy.
Renato A SinicoNephrology and Dialysis Division, IRCCS Humanitas Research Hospital, Milan, Italy.
Matija CrnogoracDepartment of Nephrology and Dialysis, Dubrava University Hospital, Zagreb, Croatia.
Stephen P McAdooRenal and Transplant Centre, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, UK.
Mark A LittleTrinity Kidney Centre, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
David JayneDepartment of Medicine, University of Cambridge, UK.
Federico AlbericiNephrology Unit, University of Brescia and ASST Spedali Civili di Brescia, Brescia, Italy.
European Vasculitis Society

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Cyclophosphamide (CYC) and rituximab (RTX), alone or combined, are the mainstays of induction therapy in antineutrophil cytoplasmic autoantibody (ANCA)-glomerulonephritis. It is unknown whether the response to induction is differentially affected by kidney histopathology. Methods: This is a retrospective, multicenter study including patients with biopsy-proven ANCA-glomerulonephritis. Cases were grouped according to the Berden nephropathology classification. Estimated glomerular filtration rate (eGFR) recovery at 6 months was defined as eGFR increase ≥ 15 ml/min per 1.73 m Results: The cohort included 304 patients; median baseline eGFR was 20 ml/min per 1.73 m Conclusion: Patients with crescentic class ANCA-glomerulonephritis receiving RTX monotherapy may have worse kidney outcomes than those treated with CYC-based regimens. Further studies are needed to validate these results and better understand how to personalize treatment.

Indexed as

ANCA-associated vasculitiscrescentscyclophosphamideoutcomesrenal biopsyrituximab

Identifiers

PMID41716736
PMCPMC12914278

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.