Evidence map›Paper›PMID 41716728›Full record

ArticleInternational journal of particle therapy2026

PTCOG Ocular Survey - Perspective on Ocular Particle Therapy: Current Practices and Emerging Trends.

Linda Mortimer, Roelf Slopsema, Alejandro Mazal, Jan-Willem Beenakker, Rémi Dendale, Andrea Denker, Emmanuelle Fleury, Anais Groulier, Andrzej Kacperek, Kavita K Mishra and 8 more

Abstract read
In one paragraph

Article in International journal of particle therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Linda MortimerMedical Physics Department, The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool, UK.
Roelf SlopsemaDepartment of Radiation Oncology, Emory University School of Medicine, Atlanta, GA, USA.
Alejandro MazalCentro de Protonterapia Quironsalud, Madrid, Spain.
Jan-Willem BeenakkerLeiden University Medical Center, Departments of Ophthalmology, Radiology and Radiation Oncology, Leiden, the Netherlands.
Rémi DendaleInstitut Curie Proton Therapy Center, Building 101, Orsay University Campus, Orsay, France.
Andrea DenkerHelmholtz-Zentrum Berlin für Materialien und Energie, Protonentherapie, Berlin, Germany.
Emmanuelle FleuryHollandPTC, Delft, the Netherlands.
Anais GroulierCentre Antoine Lacassagne, Nice, France.
Andrzej KacperekDepartment of Medical Physics and Biomedical Engineering, University College London, UK.
Kavita K MishraDepartment of Radiation Oncology, University of California, San Francisco, CA, USA.
Jatinder SainiDepartment of Radiation Oncology, University of Washington School of Medicine, Seattle, WA, USA.
Alexei V TrofimovDepartment of Radiation Oncology, Massachusetts General Hospital/Mass General Brigham, Boston, MA, USA.
Juliette ThariatUniversité de Caen Normandie, ENSICAEN, CNRS/IN2P3, LPC Caen UMR6534, Caen F-14000, France.
Petra TrnkováFaculty of Nuclear Sciences and Physical Engineering, Czech Technical University in Prague, Prague, Czech Republic.
Marie VidalCentre Antoine Lacassagne, Nice, France.
Helen A ShihDepartment of Radiation Oncology, Massachusetts General Hospital/Mass General Brigham, Boston, MA, USA.
Jan HrbacekPaul Scherrer Institut, PSI, Forschungsstrasse, Villigen, Switzerland.
Jens HeufelderCharité - Universitätsmedizin Berlin, Department of Ophthalmology and Berlin Protonen at HZB, Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To overview the status and trends in the current rapidly evolving field of ocular particle therapy (OPT). Materials and Methods: The Particle Therapy Co-Operative Group Ocular Subcommittee developed an online survey, including 127 questions, made available to treatment centers worldwide, between April 2022 and January 2024. The survey covered a broad range of topics from general program organization and beamline description, to diagnoses and patient numbers treated, treatment planning and set-up, quality assurance techniques, as well as insights into anticipated future developments. Results: Twenty facilities offered OPT by the end of 2023: 3 in Asia, 9 in Europe, and 8 in the USA. Combined, they treated, on average, 1800 patients per year, with uveal melanoma being the most common indication. The vast majority of treatments continue to be delivered on dedicated horizontal beamlines, both high (>120 Mev) and low (<75 MeV) energy. Five of the 7 recently established programs (n = 7, since 2015) use high-energy general-purpose beamlines, where some beam characteristics, including penumbrae size and dose delivery rate, differ from those typically achieved on dedicated beamlines. The evolution of the ocular treatment framework is ongoing as 9 centers reported the intent to upgrade their systems within five years, to engage state-of-the-art developments in beam delivery, imaging, and planning tools. Conclusion: Common protocols in dosimetry, dose, and fractionation have largely been adopted worldwide, while variability persists in planning, quality assurance, and delivery workflows. The obsolescence of dedicated ocular proton systems and key planning tools, and a lack of standardization, remain as pressing challenges. The adoption of non-dedicated high-energy systems on gantries and integration into multipurpose treatment environments enhances OPT accessibility, but this transition requires ongoing critical evaluation of dosimetric trade-offs and clinical outcomes. Multicenter collaboration, technological innovation, and clinical validation are essential to continued assurance of the safe and effective delivery of OPT worldwide.

Indexed as

Ocular particle therapyProton therapySurveyUveal melanoma

Identifiers

PMID41716728
PMCPMC12914457

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.