Evidence map›Paper›PMID 41716684›Full record

ArticleMediators of inflammation2026

Observational and Genetic Association of Myelodysplastic Syndromes (MDS) and Autoimmune Diseases in Adults.

Qizhao Li, Yujin Guo, Gao Xiao, Xuejing Song, Yuying Wei, Wenjuan Gao, Gege Feng, Xinyi Zuo, Xue Shi, Hongyu Zhao and 7 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Qizhao LiDepartment of Hematology, Qilu Hospital of Shandong University, Jinan, Shandong, China, qiluhospital.com.ORCID https://orcid.org/0009-0008-7713-6009
Yujin GuoDepartment of Ophthalmology, The Second Hospital of Jilin University, Changchun, China, jlu.edu.cn.ORCID https://orcid.org/0009-0005-2886-4067
Gao XiaoDepartment of Vascular Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China, sph.com.cn.ORCID https://orcid.org/0000-0003-3989-7831
Xuejing SongJinan Vocational College of Nursing, Jinan, Shandong, China.
Yuying WeiDepartment of Hematology, Qilu Hospital of Shandong University, Jinan, Shandong, China, qiluhospital.com.
Wenjuan GaoDepartment of Hematology, Qilu Hospital of Shandong University, Jinan, Shandong, China, qiluhospital.com.
Gege FengDepartment of Hematology, Qilu Hospital of Shandong University, Jinan, Shandong, China, qiluhospital.com.ORCID https://orcid.org/0000-0001-5024-081X
Xinyi ZuoDepartment of Hematology, The Affiliated Hospital of Qingdao University, Qingdao, China, qdu.edu.cn.
Xue ShiDepartment of Hematology, The Affiliated Hospital of Qingdao University, Qingdao, China, qdu.edu.cn.
Hongyu ZhaoDepartment of Hematology, Jinan Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.ORCID https://orcid.org/0000-0002-5520-1606
Yuefen HuDepartment of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China, sph.com.cn.ORCID https://orcid.org/0000-0002-2787-6884
Johan RebetzDivision of Hematology and Transfusion Medicine, Lund University, Lund, Sweden, lu.se.ORCID https://orcid.org/0000-0003-1673-0684
Elisabeth SempleDivision of Hematology and Transfusion Medicine, Lund University, Lund, Sweden, lu.se.
Li GuoBloodworks Northwest Research Institute, Seattle, Washington State, USA.
John W SempleDivision of Hematology and Transfusion Medicine, Lund University, Lund, Sweden, lu.se.ORCID https://orcid.org/0000-0002-1510-0077
Jun PengDepartment of Hematology, Qilu Hospital of Shandong University, Jinan, Shandong, China, qiluhospital.com.
Shuqian XuDepartment of Hematology, Qilu Hospital of Shandong University, Jinan, Shandong, China, qiluhospital.com.ORCID https://orcid.org/0000-0001-7071-8550

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

About 25% of patients with myelodysplastic syndromes (MDS) have combined autoimmune diseases (AIDs). However, the relationships between MDS and AIDs, especially a causal relationship and the underlying shared pathophysiological mechanisms, remain largely unknown. We aimed to evaluate the association between MDS and AIDs using a multicenter retrospective study, Mendelian randomization (MR), and bioinformatics analysis. About 26.6% of patients with MDS from all centers presented with AIDs. Compared to MDS patients without AIDs, MDS with AIDs was less likely to progress to acute myeloid leukemia (AML) (6.6% vs. 15.1%,

Indexed as

Autoimmune DiseasesMyelodysplastic SyndromesAdultAgedFemaleHumansLupus Erythematosus, SystemicMaleMiddle AgedRetrospective Studiesautoimmune diseasesbioinformatic analysisimmune cellsMendelian randomizationmulticenter retrospective studymyelodysplastic syndrome

Identifiers

PMID41716684
PMCPMC12913224

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.