ArticleMatrix biology plus2026
Regional FDL tendon properties are regulated by biglycan in a collagen VI-independent manner.
Article in Matrix biology plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Healthy tendon is associated with organized and aligned extracellular matrix (ECM) that becomes disorganized with disease, yet the mechanisms and pathogenesis of tendon disease remain poorly understood. Tendons that "wrap-around" joints, such as the flexor digitorum longus (FDL) tendon, contain a unique ECM that shares similarities with diseased tendons, which can be leveraged to study tendon cell biology across distinct loading environments. The pericellular matrix (PCM) is a critical matrix structure that is understudied in tendon and is likely involved in tendon mechanosensation and homeostasis. Two components of the tendon PCM, biglycan and collagen VI, are known regulators of tendon function and are implicated in tendon disease. Given the implication of PCM molecules in regulating tendon properties, this work sought to define the regional development of a murine wrap-around tendon, how biglycan influences these regional properties, and the extent to which these mechanisms involve collagen VI. Gene expression and histological analyses demonstrated regional divergence in FDL tendon properties by P14. While biglycan knockout did not result in broad disruptions to gene expression or the behavior of
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