ArticleFrontiers in neuroscience2026
Mapping the clinical correlates of brain hypoperfusion in behavioral variant frontotemporal dementia: insights from a SPECT imaging study.
Article in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- External validation of an integrative model of functional impairment in early-stage behavioral variant frontotemporal dementia (bvFTD).Journal of neurology · 2026Article
- Multimodal Correlates of Longitudinal Functional Decline in Behavioral Variant Frontotemporal Dementia (bvFTD).Journal of personalized medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background/objectives: Behavioral variant frontotemporal dementia (bvFTD) is characterized by heterogeneous cognitive, behavioral, and personality changes, reflecting underlying disruptions in brain structure and function. Neuroimaging, particularly single-photon emission computed tomography (SPECT) assessment of regional cerebral blood flow (rCBF), provides a valuable functional window into these alterations. Despite advances in mapping perfusion abnormalities in bvFTD, the precise relationship between region-specific brain hypoperfusion and the full spectrum of clinical manifestations remains incompletely understood. The present study aims to systematically explore these associations to clarify the neurofunctional underpinnings of bvFTD and to delineate brain-behavior relationships across cognitive, behavioral, and personality domains. Methods: rCBF was assessed in 25 individuals with early-stage bvFTD using Results: Reduced perfusion in right prefrontal regions correlated with heightened behavioral disturbances (BAs 8 and 46) and overall disease severity (BA 8). In addition, greater hypoperfusion in frontotemporal and limbic areas was linked to more pronounced declines in personality traits, including conscientiousness (left BAs 6, 31) and extraversion (right BAs 8, 32; left BA 37). A pattern of statistically significant associations also emerged between rCBF in frontal, temporal, limbic, and parietal regions and domain-specific cognitive performances, including visuoconstructional abilities (right BA 5), memory skills (left BAs 28 and 31), executive functions (left BAs 6, 31; right BAs 5, 8), and social cognition (left BA 37; right BAs 11, 32, 40, 46). In contrast, global cognitive measures showed no significant association with regional perfusion. Discussion/conclusions: These findings reveal that distinct patterns of regional hypoperfusion are selectively linked to specific cognitive, behavioral, and personality alterations in early-stage bvFTD, highlighting the neural substrates underlying its core clinical features. Identifying discrete brain regions associated with key symptoms may inform the development of more targeted therapeutic interventions, ultimately enhancing personalized management and care for individuals affected by this complex and highly disabling syndrome.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.