ArticleRSC medicinal chemistry2026
Integrating green synthesis and liquid-liquid extraction of lidocaine in deep eutectic solvents.
Article in RSC medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The development of greener and more sustainable processes for active pharmaceutical ingredients (APIs) remains a major challenge for the chemical industry. Here we present a fully integrated process for the synthesis of lidocaine carried out directly in a deep eutectic solvent, followed by a eutectic-to-eutectic liquid-liquid extraction into a hydrophobic DES for product recovery. The first step of the reaction affords the intermediate α-chloro-2,6-dimethylacetanilide in 92% isolated yield in 20 min; the subsequent S
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