Evidence map›Paper›PMID 41716654›Full record

ArticleRSC medicinal chemistry2026

Novel glycine amides, semicarbazides and fluoroallylamines as inhibitors of the amine oxidase vascular adhesion protein-1 (VAP-1).

Timo Pöstges, Jan Kampschulze, Walburga Hanekamp, Marcel Bermúdez, Matthias Lehr

Abstract read
In one paragraph

Article in RSC medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Timo PöstgesInstitute of Pharmaceutical and Medicinal Chemistry, University of Münster Corrensstrasse 48 48149 Münster Germany lehrm@uni-muenster.de.
Jan KampschulzeInstitute of Pharmaceutical and Medicinal Chemistry, University of Münster Corrensstrasse 48 48149 Münster Germany lehrm@uni-muenster.de.
Walburga HanekampInstitute of Pharmaceutical and Medicinal Chemistry, University of Münster Corrensstrasse 48 48149 Münster Germany lehrm@uni-muenster.de.
Marcel BermúdezInstitute of Pharmaceutical and Medicinal Chemistry, University of Münster Corrensstrasse 48 48149 Münster Germany lehrm@uni-muenster.de.ORCID https://orcid.org/0000-0002-7421-3282
Matthias LehrInstitute of Pharmaceutical and Medicinal Chemistry, University of Münster Corrensstrasse 48 48149 Münster Germany lehrm@uni-muenster.de.ORCID https://orcid.org/0000-0003-1645-7913

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vascular adhesion protein-1 (VAP-1), also known as copper-containing amine oxidase 3 (AOC3), is an enzyme implicated in the pathogenesis of various diseases. Increasing evidence highlights VAP-1 as a promising therapeutic target, particularly for the treatment of inflammatory disorders and diabetic complications. We have synthesised a series of compounds in which a heterocycle or a benzene-fused heterocycle is connected

Identifiers

PMID41716654
PMCPMC12914920

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.