Evidence map›Paper›PMID 41716599›Full record

ArticleGastro hep advances2026

Use of a Novel Self-assembling Peptide Gel for Prevention of Bleeding After Endoscopic Mucosal Resection of Large Nonpedunculated Sessile Colorectal Polyps: A Case-Control Study.

Victoria R Barone, Michael Ma, Sumant Inamdar, Lionel D'Souza, Henry Jen, Sherif Andrawes, Kazi Ullah, Nimra Hameed, Antonio Costantino, Hassan Al Moussawi and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gastro hep advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Victoria R BaroneDivision of Gastroenterology, Long Island Jewish Medical Center, Zucker School of Medicine at Hofstra/Northwell, Northwell Health System, New Hyde Park, New York.
Michael MaDivision of Gastroenterology, Long Island Jewish Medical Center, Zucker School of Medicine at Hofstra/Northwell, Northwell Health System, New Hyde Park, New York.
Sumant InamdarDivision of Gastroenterology, University of Arkansas, Little Rock, Arkansas.
Lionel D'SouzaDivision of Gastroenterology and Hepatology, Stony Brook University Hospital, Stony Brook, New York.
Henry JenDivision of Gastroenterology, Long Island Jewish Forest Hills Medical Center, Zucker School of Medicine at Hofstra/Northwell, Northwell Health System, Forest Hills, New York.
Sherif AndrawesDivision of Gastroenterology and Hepatology, Staten Island University Hospital, Zucker School of Medicine at Hofstra/Northwell, Northwell Health System, Staten Island, New York.
Kazi UllahDivision of Gastroenterology and Hepatology, Stony Brook University Hospital, Stony Brook, New York.
Nimra HameedDivision of Gastroenterology and Hepatology, Stony Brook University Hospital, Stony Brook, New York.
Antonio CostantinoDivision of Gastroenterology, South Shore University Hospital, Zucker School of Medicine at Hofstra/Northwell, Northwell Health System, New Hyde Park, New York.
Hassan Al MoussawiDivision of Gastroenterology and Hepatology, Staten Island University Hospital, Zucker School of Medicine at Hofstra/Northwell, Northwell Health System, Staten Island, New York.
Nichol MartinezDivision of Gastroenterology, North Shore University Hospital, Zucker School of Medicine at Hofstra/Northwell, Northwell Health System, Manhasset, New York.
Juan Carlos BucoboDivision of Gastroenterology, North Shore University Hospital, Zucker School of Medicine at Hofstra/Northwell, Northwell Health System, Manhasset, New York.
Molly StewartDivision of Gastroenterology, Long Island Jewish Medical Center, Zucker School of Medicine at Hofstra/Northwell, Northwell Health System, New Hyde Park, New York.
Arvind J TrindadeDivision of Gastroenterology, Long Island Jewish Medical Center, Zucker School of Medicine at Hofstra/Northwell, Northwell Health System, New Hyde Park, New York.
Petros C BeniasDivision of Gastroenterology, Rutgers University School of Medicine, New Brunswick, New Jersey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aims: Endoscopic mucosal resection (EMR) of large nonpedunculated colorectal lesions (LNPCLs) carries a risk of delayed bleeding. To prevent this, the EMR defect can be clipped closed. However, this is often not possible with larger defects. Recently, a self-assembling peptide gel has become available, which may reduce delayed bleeding by creating a liquid bandage. There are limited data on the effectiveness of this agent. The aim of this study was to evaluate the gel for the prevention of delayed bleeding. Methods: This is a multicenter retrospective case-control study from February 2019-February 2024 of consecutive patients undergoing EMR of LNPCLs not amenable to closure. Cases were patients with gel applied post EMR for prevention of bleeding vs controls without gel application. The primary outcome was the rate of gastrointestinal bleeding postprocedure. Results: A total of 176 patients were enrolled from 6 centers; of which, 94 lesions were cases and 91 were controls. The groups were statistically equivalent for bleeding risk factors. Postprocedural bleeding occurred in 11 cases vs 3 controls (12% vs 3%; Conclusion: Use of a novel self-assembling peptide gel after EMR of LNPCLs was associated with delayed bleeding. This observation needs to be validated in a prospective study.

Indexed as

BleedingColonoscopyColorectal LesionEndoscopic Mucosal ResectionSelf-assembling Peptide Gel

Identifiers

PMID41716599
PMCPMC12914181

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.