Evidence map›Paper›PMID 41716522›Full record

ArticleUrology case reports2026

Pure large-cell neuroendocrine carcinoma of the bladder with pelvic organ invasion: A case report.

Sami Chebbi, Houssem Bel Hadj Alouane, Mohamed Amine Oueslati, Raoueh Hedhli, Ehsen Ben Brahim, Sami Ben Rhouma

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Urology case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sami ChebbiUniversity of Tunis El Manar, Faculty of Medicine, Habib Thameur Hospital, Tunis, Urology Department, Tunisia.
Houssem Bel Hadj AlouaneUniversity of Tunis El Manar, Faculty of Medicine, Habib Thameur Hospital, Tunis, Urology Department, Tunisia.
Mohamed Amine OueslatiUniversity of Tunis El Manar, Faculty of Medicine, Habib Thameur Hospital, Tunis, Urology Department, Tunisia.
Raoueh HedhliUniversity of Tunis El Manar, Faculty of Medicine, Habib Thameur Hospital, Tunis, Pathology Department, Tunisia.
Ehsen Ben BrahimUniversity of Tunis El Manar, Faculty of Medicine, Habib Thameur Hospital, Tunis, Pathology Department, Tunisia.
Sami Ben RhoumaUniversity of Tunis El Manar, Faculty of Medicine, Habib Thameur Hospital, Tunis, Urology Department, Tunisia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Large-cell neuroendocrine carcinoma (LCNEC) of the bladder is a rare, high-grade malignancy with aggressive behavior. We report a 69-year-old woman presenting with recurrent macroscopic hematuria. Imaging revealed a large tumor of the bladder floor involving the right ureterovesical junction, with local extension to adjacent pelvic organs but no nodal or distant metastases. Histology and immunohistochemistry confirmed pure LCNEC. She received four cycles of carboplatin-etoposide, followed by anterior pelvic exenteration with ileal conduit diversion. Postoperative recovery was uneventful, and early follow-up showed no recurrence. The case illustrates the complexity of managing locally advanced bladder LCNEC and supports individualized multimodal therapy.

Indexed as

Bladder cancerLarge-cell neuroendocrine carcinomaPelvic exenterationPlatinum-based chemotherapy

Identifiers

PMID41716522
PMCPMC12914279

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.