ArticleHealth science reports2026
Protective Role of Vitamins C, D, and K in the Management of Dengue: A Narrative Review to Combat the Dengue Outbreak.
Article in Health science reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Vitamin D and Intestinal Diseases: Impact on Intestinal Immunity and Gut Barrier Function.Diseases (Basel, Switzerland) · 2026Review
- The Role of Natural Killer (NK) Cells in Dengue Virus Infection: A Narrative Review.Health science reports · 2026Article
- Protective Role of Vitamins C, D, and K in the Management of Dengue: A Narrative Review to Combat the Dengue Outbreak.Health science reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: Dengue fever is mostly found in tropical and subtropical regions and is spread by mosquitoes. Still now, no specific antiviral medication is available against the disease. However, several vitamins have been identified as potential dengue therapy supplements. Therefore, this study aimed to comprehensively gather data on the protective role of vitamins C, D, and K in the treatment of dengue fever. Methods: To conduct the present narrative review, we retrieved data from Google Scholar, Web of Science, PubMed, Cochrane Library, BanglaJOL, Embase, and Scopus regarding the influence of vitamin supplements in dengue treatment. Articles published in English before March 2025 were included in the study. Results and Discussion: This review explored how vitamin C neutralizes reactive oxygen species and reduces inflammation and oxidative damage in dengue infection. It stimulates chemotaxis and NK cell activity and controls the activities of monocytes, macrophages, phagocytosis, and the release of cytokines that promote inflammation. While shielding neutrophils from oxidative damage, it also promotes ROS production, which is essential for pathogen removal. Additionally, vitamin D possesses antiviral and immunomodulatory properties that help to fight dengue virus (DENV). It regulates the course of the disease in DENV-infected individuals by modifying immunological responses. It can limit viral replication, decrease the expression of DENV entry receptors, and alter the expression of inflammatory cytokines in cells infected with the virus. Moreover, vitamin K is recommended in cases of dengue-related hepatic failure and encephalopathy. The administration of vitamin K in early dengue hemorrhagic fever (DHF) may help to avoid anemia and lessen the need for transfusions. Conclusion: By targeting important pathogenic processes, the adjunctive use of vitamins C, D, and K together provides an effective supplemental strategy in the dengue management and provides a good patient outcome in future dengue outbreak.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.